摘要
目的:探讨硫酸沙丁胺醇联合噻托溴铵联合治疗对慢性阻塞性肺疾病急性发作炎症因子的影响。方法:选取2019年1月-2020年6月我院收治的78例慢性阻塞性肺疾病急性发作患者临床资料,按治疗用药情况分成噻托溴铵组;联合组。噻托溴铵组给予噻托溴铵吸入粉雾剂,联合组在此基础上给予硫酸沙丁胺醇,均连续治疗7天,比较两组治疗效果及炎症指标。结果:治疗后,联合组白细胞介素IL-6、hs-CRP、TNF-α、及PCT水平均低于噻托溴铵组,差异有统计学意义(P<0.05)。治疗后,两组PaCO_(2)水平均低于治疗前,PaO_(2)、SaO_(2)水平均高于治疗前,且联合组PaCO_(2)、PaO_(2)、SaO_(2)水平均比噻托溴铵组的变化更明显,差异有统计学意义(P<0.05)。治疗后两组不良反应总发生率差异无统计学意义(P>0.05)。结论:硫酸沙丁胺醇联合噻托溴铵联合治疗慢性阻塞性肺疾病急性发作比噻托溴铵单一用药时效果更佳,有效改善血氧平衡,抑制炎症反应,且其不良反应较少,安全性较高。
Objective:To investigate the effect of salbutamol sulfate combined with tiotropium bromide on inflammatory factors in acute attack of chronic obstructive pulmonary disease.Methods:Clinical data of 78 patients with acute attack of chronic obstructive pulmonary disease treated in our hospital from January 2019 to June 2020 were selected and divided into tiotropium bromide group and combination group according to treatment and medication.The tiotropium bromide group was given tiotropium bromide inhalation powder aerosol,and the combined group was given salbutamol sulfate on this basis,all of which were treated for 7 consecutive days,to compare the therapeutic effect and inflammatory indicators of the two groups.Results:After treatment,the levels of interleukin-6,hs-CRP,TNF-α,and PCT in the combined group were lower than those in the tiotropium bromide group,and the difference was statistically significant(P<0.05).After treatment,PaCO_(2) levels in both groups were lower than before treatment,PaO_(2) and SaO_(2) levels were higher than before treatment,and the changes of PaCO_(2),PaO_(2) and SaO_(2) levels in the combined group were more obvious than those in the tiotropium bromide group,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion:Salbutamol sulfate combined with tiotropium bromide in the treatment of acute exacerbation of chronic obstructive pulmonary disease is more effective than tiotropium bromide alone in improving blood oxygen balance,inhibiting inflammatory reaction,and has fewer adverse reactions and higher safety.
作者
黄绮健
林泳祺
明颖
HUANG Qi-jian;LIN Yong-qi;MING Ying(The pharmaceutical department,the central hospital of chaticheng district,foshan,Guangdong,528000)
出处
《岭南急诊医学杂志》
2021年第1期33-35,共3页
Lingnan Journal of Emergency Medicine
