摘要
Intermittent fasting(IF)is becoming a prevailing topic worldwide,as it can cause changes in the body’s energy metabolism processes,improve health,and affect the progression of many diseases,particularly in the circumstance of oncology.Recent research has shown that IF can alter the energy metabolism of tumor cells,thereby inhibiting tumor growth and improving antitumor immune responses.Furthermore,IF can increase cancer sensitivity to chemotherapy and radiotherapy and reduce the side effects of these traditional anticancer treatments.IF is therefore emerging as a promising approach to clinical cancer treatment.However,the balance between long-term benefits of IF compared with the harm from insufficient caloric intake is not well understood.In this article,we review the role of IF in tumorigenesis and tumor therapy,and discuss some scientific problems that remain to be clarified,which might provide some assistance in the application of IF in clinical tumor therapy.
基金
supported by the Program for Highlevel Innovative Talents in Guizhou Province(Grant No.QKH-RC-2016-4031)
the National Natural Science Foundation of China(Grant No.31760258)
the Program for New Century Excellent Talents in University,the Ministry of Education of China(Grant No.NCET-12-0661)
the Program for Excellent Young Talents of Zunyi Medical University(Grant No.15ZY-001)
the Project of the Guizhou Provincial Department of Science and Technology(Grant No.QKH-JC-2018-1428)。
