摘要
目的:探讨桃红四物汤对桡骨远端骨折患者腕关节功能及骨代谢的影响。方法:选取2017年3月—2019年3月我院正骨科收治的120例桡骨远端骨折患者,按随机数字表法将其分为对照组(60例)和观察组(60例)。对照组采用手法复位夹板外固定进行治疗,观察组在此基础上给予桃红四物汤进行治疗,治疗8周。比较两组术后8周的临床疗效;对比两组术前、术后8周的血流流变学指标、骨代谢指标水平及腕关节功能和视觉模拟评分(VAS)评分;统计两组治疗期间的并发症发生率。结果:观察组总有效率为96.67%(58/60),高于对照组的80.00%(48/60)(P<0.05)。与术前相比,术后8周,两组腕关节功能评分均升高,且观察组高于对照组(P<0.05);两组VAS评分均降低,且观察组低于对照组(P<0.05);两组全血高切黏度、全血中切黏度、全血低切黏度水平均降低,且观察组低于对照组(P<0.05);两组血清碱性磷酸酶(ALP)、骨钙素(BGP)、护骨素(OPG)水平均升高,且观察组高于对照组(P<0.05)。观察组并发症发生率为5.00%,低于对照组的13.33%(P<0.05)。结论:桃红四物汤治疗桡骨远端骨折,可明显升高患者血清ALP、BGP、OPG水平,增强腕关节功能,并能减轻患者疼痛,降低其并发症发生率,疗效显著。
Objective:To investigate the effect of Taohong Siwu Decoction on wrist joint function and bone metabolism in patients with distal radius fractures.Methods:A total of 120 patients with distal radius fractures were randomly divided into the control group(n=60)and the observation group(n=60).The control group was treated with manual reduction and splint external fixation;on which basis,the observation group was also treated with Taohong Siwu Decoction.The clinical efficacy was compared between the two groups after 8 weeks of the treatment.The levels of bone metabolism,hemorheology index and the scores of wrist function and visual analogue score(VAS)were compared before and after 8 weeks of the manipulation,and the incidence of complications was counted during the treatment in the two groups.Results:The total effective rate was 96.67%(58/60)in the observation group,which was significantly higher than 80.00%(48/60)in the control group(P<0.05).The scores of wrist joint function were increased after the treatment compared to those before the treatment in the two groups;of which the increases in the observation group were more significant than those in the control group(P<0.05).The scores of VAS were decreased after the treatment in the two groups;of which the decreases in the observation group were more significant(P<0.05).The whole blood high-shear viscosity,the whole blood medium-shear viscosity,and the whole blood low-shear viscosity decreased in both groups,of which the observation group was lower than the control group(P<0.05).The serum levels of alkaline phosphatase(ALP),bone glaprotein(BGP)and osteoprotegerin(OPG)were increased in the two groups,of which the improvements were more significant in the observation group(P<0.05).The incidence of complications was 5.00%in the observation group,which was significantly lower than 13.33%in the control group(P<0.05).Conclusion:Taohong Siwu Decoction combined with manual reduction and splint external fixation can significantly increase the serum levels of ALP,BGP and OPG i
作者
江继君
刘兴坤
董霞
刘枝城
JIANG Jijun;LIU Xingkun;DONG Xia;LIU Zhicheng(Emergency Department of Sichuan Orthopedic Hospital,Chengdu 610041,China)
出处
《中医药学报》
CAS
2021年第4期69-73,共5页
Acta Chinese Medicine and Pharmacology
基金
川干研课题资助项目(2017-604)。
关键词
桡骨远端骨折
桃红四物汤
手法复位夹板外固定
碱性磷酸酶
骨钙素
护骨素
腕关节功能
Distal radius fracture
Taohong Siwu Decoction
Manual reduction and splint external fixation
Alkaline phosphatase
Osteocalcin
Osteoprotegerin
Wrist joint function
