摘要
目的:探究血清及尿液抗炎因子及促炎因子在感染性肾结石患者中的检测价值。方法:选取2018年12月-2019年12月于本院就诊的86例感染性肾结石患者为观察组,同时期的86名体检健康者为对照组。检测与比较两组的血清及尿液抗炎因子(IL-2及IL-10)及促炎因子(IL-1β及IL-6),同时比较观察组中不同S.T.O.N.E评分及白细胞水平者的检测结果,分析各指标与S.T.O.N.E评分及白细胞水平的关系。结果:观察组的血清及尿液IL-2均显著低于对照组(P<0.05),血清及尿液IL-10、IL-1β及IL-6均显著高于对照组(P<0.05),观察组中不同S.T.O.N.E评分及白细胞水平者的检测结果比较,差异均有统计学意义(P<0.05)。Spearman秩相关分析显示,血清及尿液IL-2与S.T.O.N.E评分及白细胞水平呈负相关(P<0.05),血清及尿液IL-10、IL-1β及IL-6与S.T.O.N.E评分及白细胞水平呈正相关(P<0.05)。结论:血清及尿液抗炎因子及促炎因子在感染性肾结石患者中呈现异常表达的状况,对于结石情况及炎性反应程度有较高的检测价值。
Objective:To investigate the detection value of serum and urine antiinflammatory and proinflammatory factors of patients with infectious nephrolithiasis.Method:A total of 86 patients with infectious nephrolithiasisadmitted to our hospital from December 2018 to December 2019 were selected as the observation group,86 healthy subjects during the same period were selected as the control group.Then the serum and urine antiinflammatory factors(IL-2 and IL-10)and proinflammatory factors(IL-1βand IL-6)of two groups were detected and compared,then the detection results of observation group with different S.T.O.N.E scores and leukocyte levels were compared,the relationship between those indexes and S.T.O.N.E scores,leukocyte levels were analyzed.Result:The serum and urine IL-2 of observation group were significantly lower than those of control group(P<0.05),the serum and urine IL-10,IL-1βand IL-6 were significantly higher than those of control group(P<0.05),the detection results of observation group with different S.T.O.N.E scores and leukocyte levels were compared,there were statistically significant differences(P<0.05).The Spearman rank correlation analysis showed the serum and urine IL-2 were negatively correlated with S.T.O.N.E scores and leukocyte levels(P<0.05),the serum and urine IL-10,IL-1βand IL-6 were positively correlated with S.T.O.N.E scores and leukocyte levels(P<0.05).Conclusion:The serum and urine antiinflammatory and proinflammatory factors of patients with infectious nephrolithiasis show abnormal expression state,the detection value for nephrolithiasis situation and inflammatory response degree are higher.
作者
曲丹丹
张雪
QU Dandan;ZHANG Xue(Jiamusi Central Hospital,Jiamusi 154002,China;不详)
出处
《中国医学创新》
CAS
2021年第7期159-162,共4页
Medical Innovation of China
关键词
血清
尿液
抗炎因子
促炎因子
感染性肾结石
检测价值
Serum
Urine
Antiinflammatory factors
Proinflammatory factors
Infectious nephrolithiasis
Detection value
