摘要
为拓展稀土掺杂上转换纳米粒子(UCNPs)独立用于药物载体及对于癌细胞的靶向性识别功能,我们采用简单的溶剂热法,通过调节溶剂热的时间和温度、添加剂以及表面活性剂的用量一步合成生物相容性较好的上转换纳米粒子.合成具有形貌、粒径可调节的高均匀性和分散性的UCNPs.研究了NaYF_(4):Yb^(3+)/Tm^(3+)的合成条件,获得最佳尺寸(约300 nm)及形貌的NaYF_(4):Yb^(3+)/Tm^(3+)纳米粒子.探讨其荧光性质,发现其在980 nm光激发下的强蓝色发射可用于荧光成像,证明我们合成的UCNPs可作为上转换荧光的发光中心.对最优NaYF_(4):Yb^(3+)/Tm^(3+)纳米粒子进行药物(DOX)递送测试,发现该药物可以实现pH响应释放.至此,我们成功合成同时具有载药及pH响应释放功能的上转换纳米粒子,实现荧光成像引导下的诊疗一体化功能,拓展UCNPs的独立应用范围.
In order to expand the independent use of UCNPs as drug carriers and the targeted recognition function of cancer cells,we adopted a simple solvothermal method.By adjusting the time and temperature of solvothermal,the amount of additives and surfactants,the biocompatibility of the synthesis Good up-conversion nanoparticles.Synthesize rare earth-doped up-conversion nanoparticles(UCNPs)with adjustable morphology,particle size,high uniformity and dispersion.The synthesis conditions of NaYF_(4):Yb^(3+)/Tm^(3+)are studied,and the best size(about 300 nm)and the morphology of NaYF_(4):Yb^(3+)/Tm^(3+)nanoparticles.The fluorescence properties were discussed,and it was found that its strong blue emission under 980 nm light excitation can be used for fluorescence imaging,which proves that our synthesized UCNPs can be used as the emission center of upconversion fluorescence.The optimal NaYF_(4):Yb^(3+)/Tm^(3+)nanoparticles were tested for drug(DOX)delivery,and it was found that the drug can achieve pH-responsive release.So far,we have successfully synthesized up-conversion nanoparticles with both drug-loading and pH-responsive release functions.The integrated function of diagnosis and treatment under the guidance of fluorescence imaging has expanded the independent application range of UCNPs.
作者
许明悦
田丰
高海清
肖梓伊
李玲
XU Mingyue;TIAN Feng;GAO Haiqing;XIAO Ziyi;LI Ling(Collaborative Innovation Center of Hubei Advanced Organic Chemical Materials,Key Laboratory of Organic Synthesis and Application of Ministry of Education,College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062,China)
出处
《湖北大学学报（自然科学版）》
CAS
2021年第3期303-307,334,共6页
Journal of Hubei University：Natural Science
基金
国家自然科学基金(51302071)资助。
关键词
上转换纳米粒子
一步合成
可调控
上转换荧光
载药
PH响应
Up-conversion nanoparticles
one-step synthesis
adjustable
up-conversion fluorescence
drug loading
pH response
