摘要
苦参碱对心脏具有正性肌力和负性频率作用,在低浓度时可降低心肌自律性、高浓度时可提高其自律性。其正性肌力作用的机制系促进外钙内流,从而促进心肌细胞内的肌浆网钙大量释放所致;而负性自律性产生的机制主要与阻滞钾离子通道和钠离子通道、使动作电位时程(APD)和有效不应期(ERP)延长从而消除折返激动有关。故苦参碱可防治心力衰竭、心肌缺血、电刺激和各种化学品引起的心律失常的治疗。文中就苦参碱抗心律失常的临床治疗及其作用机制的文献做了综述,分析了其研究进展。
Matrine has positive inotropic and negative frequency effects on the heart,which could reduce the automaticity of the heart at low concentration and improve it at high concentration.The mechanism of positive inotropic action is promoting extracellular calcium to flow into intracellular,thus promoting Ca2+release of sarcoplasmic reticulum in myocardium.The mechanism of negative automaticity may principally relate to blocking K+channel and Na+channel,thus prolonging effective refractory period(ERP)and action potential duration(APD)to eliminate reentry impulse.Matrine can prevent and treat arrhythmia induced by heart failure,myocardial ischemia,electric impulse and various chemicals.In this paper,the literatures on clinical medication and mechanism of matrine anti-arrhythmia were reviewed and their research progress was analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2021年第2期153-158,共6页
Anti-infection Pharmacy
关键词
苦参碱
心律失常
心力衰竭
心肌缺血
临床治疗
matrine
arrhythmia
heart failure
myocardial ischemia
clinical medication
