摘要
目的分析不同类型急性孤立性脑桥梗死(AIPI)患者基底动脉的高分辨血管壁成像(HR-VWI)特点,探讨AIPI的发病机制。方法回顾性分析深圳市宝安区人民医院MR室自2016年6月至2019年12月检查的52例AIPI患者的临床及影像学资料。根据患者弥散加权成像(DWI)上病灶的形态和分布将其分为旁正中脑桥梗死(PPI)组和深部脑桥小梗死(SDPI)组,比较2组患者的临床资料,入院、出院时改良美国国立卫生研究院卒中量表(mNIHSS)评分和改良Rankin量表(mRS)评分以及HR-VWI上基底动脉斑块的发生率和特征。结果与SDPI组比较,PPI组患者入院、出院时mNIHSS评分较高,差异均有统计学意义(P<0.05)。PPI组患者基底动脉斑块的发生率明显高于SDPI组(92.9%vs.62.5%),差异有统计学意义(P<0.05)。与SDPI组比较,PPI组患者右侧壁斑块的发生率较高,腹侧壁斑块的发生率较低,向心性型斑块的发生率较高,血管壁最厚厚度增加,差异均有统计学意义(P<0.05)。结论AIPI的发病机制与基底动脉的分支动脉粥样硬化病有关。PPI患者的临床症状、基底动脉斑块堵塞穿支开口均较SDPI更为严重,且基底动脉斑块较SDPI不稳定。
Objective To investigate the high resolution vessel wall imaging(HR-VWI)features of basilar artery(BA)in patients with acute isolated pontine infarction(AIPI)of different infarct types,and explore the pathogenesis of AIPI.Methods A retrospective analysis of clinical and imaging data of 52 patients with AIPI admitted to our hospital from June 2016 to November 2019 was performed.According to the morphology and location distribution of pontine high-signal lesions in diffusion-weighted imaging(DWI),these patients were divided into paramedian pontine infarction(PPI)group and small deep pontine infarction(SDPI)group.The general clinical data,modified National Institute of Health stroke scale(mNIHSS)scores at admission and discharge,modified Rankin scale(mRS)scores,and incidence of basilar artery plaques and plaque characteristics of basal artery in HR-VWI of patients from the two groups were compared.Results Among the 52 AIPI patients,there were 28 patients with PPI(54%)and 24 with SDPI(46%).The mNIHSS scores at admission and discharge in the PPI group were significantly higher than those in the SDPI group(P<0.05).The incidence of basilar artery plaques in PPI group was significantly higher than that in SDPI group(92.9%vs.62.5%,P<0.05).As compared with SDPI group,PPI group had a significantly higher incidence of right lateral wall plaques,a statistically lower incidence of ventral wall plaques,and a significantly higher incidence of centripetal plaques,and significantly increased maximum thickness of vessel wall(P<0.05).Conclusion The AIPI mechanism is generally related to the branch atheromatous disease of basilar artery;PPI patients have more severe clinical symptoms,more serious clogged perforation opening of the basilar artery plaque,more unstable basilar artery plaque than the SDPI group.
作者
钟丽玲
宋建勋
徐棣豪
陈思静
Zhong Liling;Song Jianxun;Xu Dihao;Chen Sijing(Department of MR Room,Shenzhen Baoan People's Hospital,Shenzhen 518100,China;First Clinical Medicine School,Guangdong Medical University,Zhanjiang 524023,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2021年第3期275-281,共7页
Chinese Journal of Neuromedicine
关键词
急性孤立性脑桥梗死
高分辨血管壁成像
旁正中脑桥梗死
深部脑桥小梗死
动脉粥样硬化斑块
Acute isolated pontine infarction
High-resolution vascular wall imaging
Paramedian pontine infarction
Small deep pontine infarction
Atherosclerotic plaque
