摘要
目的探讨丙戊酸钠缓释片治疗老年癫痫对患者临床疗效的影响。方法方便选取2017年7月-2019年7月于该院就诊的86例老年癫痫患者,按随机数字表法分为两组,各43例。对照组予以托吡酯片治疗,观察组采用丙戊酸钠缓释片治疗。比较两组临床疗效、癫痫发作状况、实验室指标及不良反应发生状况。结果观察组临床总有效率为93.02%,高于对照组,差异有统计学意义(χ^(2)=4.441,P=0.035);两组治疗前癫痫发作状况及实验室指标相比,差异无统计学意义(P>0.05);观察组治疗后发作持续时间及发作次数为(2.53±0.52)min、(2.64±0.43)次,少于对照组,差异有统计学意义(t=4.648、7.242,P<0.05);观察组治疗后神经元特异性烯醇化酶(NSE)、谷氨酸(Glu)、超氧化物岐化酶(SOD)、γ-氨基丁酸(γ-GABA)水平为(9.57±1.63)μg/L、(34.09±2.25)μmol/L、(267.34±15.52)n U/mL、(57.03±2.05)μmol/L,低于对照组,脑源性神经营养因子(BDNF)水平为(9.45±2.16)μg/L,高于对照组,差异有统计学意义(t=8.920、6.295、7.002、8.478、5.121,P<0.05);观察组不良反应发生率为4.65%,低于对照组,差异有统计学意义(χ^(2)=6.198,P=0.013)。结论丙戊酸钠缓释片治疗可提高老年癫痫患者临床疗效,减少癫痫发作次数,降低NSE、Glu、SOD、γ-GABA水平,安全可靠。
Objective To investigate the effect of sodium valproate sustained-release tablets on the clinical efficacy of senile epilepsy.Methods A total of 86 elderly patients with epilepsy who were treated in the hospital from July 2017 to July 2019 were conveniently selected and divided into two groups according to the random number table method,with 43 cases in each group.The control group was treated with topiramate tablets,and the observation group was treated with sodium valproate sustained-release tablets.The clinical efficacy,epileptic seizure status,laboratory indicators and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 93.02%,which was higher than that of the control group.The difference was statistically significant(x2=4.441,P=0.035);there was not statistically significant difference between the two groups of seizure status and laboratory indicators before treatment(P>0.05);the duration of seizures and the number of seizures after treatment in the observation group were(2.53±0.52)min and(2.64±0.43)times,which were less than those in the control group.The difference was statistically significant(t=4.648,7.242,P<0.05);the neuron-specific enolase(NSE),glutamate(Glu),superoxide dismutase(SOD)andγ-aminobutyric acid(γ-GABA)levels in the observation group after treatment were(9.57±1.63)μg/L,(34.09±2.25)μmol/L,(267.34±15.52)nU/mL,(57.03±2.05)μmol/L,lower than the control group,brain-derived neurotrophic factor(BDNF)level(9.45±2.16)μg/L,higher than the control group,the difference was statistically significant(t=8.920,6.295,7.002,8.478,5.121,P<0.05);adverse reactions in the observation group was 4.65%,which was lower than that of the control group,and the difference was statistically significant(x2=6.198,P=0.013).Conclusion The treatment of sodium valproate sustainedrelease tablets can improve the clinical efficacy of elderly patients with epilepsy,reduce the number of seizures,and reduce the levels of NSE,Glu,SOD,andγ-GABA.It is
作者
殷卓琳
YIN Zhuo-lin(Department of Neurology,Jilin Provincial People's Hospital,Changchun,Jilin Province,130021 China)
出处
《中外医疗》
2021年第5期100-102,109,共4页
China & Foreign Medical Treatment
关键词
老年癫痫
丙戊酸钠缓释片
托吡酯
超氧化物岐化酶
不良反应
Senile epilepsy
Sodium valproate sustained-release tablets
Topiramate
Superoxide dismutase
Adverse reactions
