摘要
抑郁障碍现已成为世界范围内导致死亡和残疾的主要原因之一,其发病机制目前尚无确切定论。近年来,越来越多的学者认为,抑郁障碍的发生可能与应激反应有关。应激反应会引起神经可塑性改变、下丘脑-垂体-肾上腺轴异常以及神经递质变化,造成大脑结构和功能的紊乱,最终导致抑郁障碍的发生。
Depressive disorder has become one of the main causes of death and disability in the world,and its pathogenesis has not yet been determined.In recent years,more and more scholars believe that the occurrence of depression may be related to stress response.Stress response may cause changes in plasticity of nerve cells,abnormal regulation of hypothalamus pituitary adrenal axis and changes of neurotransmitter secretion,resulting in brain structure and function disorders,and eventually lead to the occurrence of depression.
作者
程洋英林
邬素萍
Cheng Yangyinglin;Wu Suping(Mental Health Center,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《神经疾病与精神卫生》
2021年第1期65-69,共5页
Journal of Neuroscience and Mental Health
关键词
抑郁障碍
应激
神经可塑性
HPA轴
综述
Depression disorders
Stress
Neural plasticity
Hypothalamus pituitary adrenal axis(HPA axis)
Review