摘要
衰弱是指一种由于机体退行性改变和多种慢性疾病引起的机体易损性增加的老年综合征,与一系列负性临床事件相关。衰弱的发病机制尚不明确,人群队列和观察性研究在衰弱的生物学特征方面取得了进展,主要包括下丘脑-垂体-肾上腺及神经内分泌失调、慢性炎症与免疫系统衰老、细胞衰老、能量代谢受损和社会环境心理因素及躯体疾病等。本文对老年衰弱综合征的发病机制进行综述。
Frailty is a geriatric syndrome characterized by increased vulnerability to degenerative changes and various chronic diseases,and is associated with a series of negative clinical events.The pathogenesis of frailty is unclear,and population cohort and observational research has made progress in understanding the biological characteristics of frailty,especially about the hypothalamic-pituitary-adrenal axis and neuroendocrine dysfunction,chronic inflammation and immune system ageing,cell senescence,energy metabolism dysfunction,social environmental psychological factors and chronic diseases,among others.This article reviews the pathogenesis of frailty in the elderly.
作者
马丽娜
Ma Lina(Department of Geriatrics,Xuanwu Hospital,Capital Medical University,National Research Center for Geriatric Diseases,Beijing 100053,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2021年第3期379-382,共4页
Chinese Journal of Geriatrics
关键词
衰弱
发病机制
Frailty
Pathogenesis
