摘要
Two sulfo nated seco C_(20)-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the structures were elucidated by various spectroscopic data,combined with X-ray crystallogra phic analysis.The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture.The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test.
基金
Financial support from the National Natural Sciences Foundation of China(Nos.81630094 and 81573445)
CAMS Innovation Fund for Medical Science(Nos.2017-I2M-3-010,2017-I2M-3-011,and 2016-I2M-1-010)
The Drug Innovation Major Project(2018ZX09711001-003-001)is acknowledged。
