摘要
目的探讨N-乙酰半胱氨酸联合布地奈德对老年慢性阻塞性肺疾病急性加重期(AECOPD)患者的疗效及对其气道高反应性的影响。方法选取2016年3月至2018年10月收治的老年AECOPD患者150例,随机分为对照组(布地奈德酸治疗)和观察组(N-乙酰半胱氨酸+布地奈德治疗),每组75例,均给予常规治疗。2组疗程均为1个月。比较2组患者治疗前后的肺功能,比较2组临床疗效,比较2组患者治疗前后的气道高反应性指标,比较2组不良反应发生情况。结果治疗前2组第1秒用力呼吸容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量的比值(FEV1/FVC%)差异无统计学意义(P>0.05);治疗后2组的FEV1、FVC、FEV1/FVC%较治疗前均显著升高(P<0.05),且观察组显著高于对照组(P<0.05);2组总有效率差异有统计学意义(P<0.05),且观察组总有效率显著高于对照组(P<0.05);治疗前2组气道阻力及肺顺应性差异无统计学意义(P>0.05);治疗后2组患者的气道阻力均显著降低(P<0.05),肺顺应性均显著升高(P<0.05),且治疗后观察组的气道阻力显著低于对照组(P<0.05),肺顺应性显著高于对照组(P<0.05);2组不良反应发生情况差异无统计学意义(P>0.05)。结论N-乙酰半胱氨酸联合布地奈德可有效改善老年AECOPD患者的肺功能,提高临床疗效,降低气道高反应性,且安全性好。
Objective To investigate the therapeutic effects of N-acetylcysteine combined with budesonide on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in elderly patients and its effects on airway hyperresponsiveness.Methods A total of 150 elderly patients with AECOPD who were treated in our hospital from March 2016 to October 2018 were enrolled in the study,who were randomly divided into control group and observation group,with 75 cases in each group.The patients in both groups were treated by routine treatment,on that basis,the patients in control group were treated by budesonide,however,the patients in observation group were treated by N-acetylcysteine combined with budesonide,with a treatment course of 1 month for both groups.The lung function before and after treatment,and clinical curative effects,and the airway hyperreactivity before and after treatment as well as the incidence rates of adverse reactions were observed and compared between the groups.Results Before treatment,there were no significant differences in FEV1,FVC and FEV1/FVC%ratio between the two groups(P>0.05).After treatment,the levels of FEV1,FVC and FEV1/FVC%in both groups were significantly increased(P<0.05),moreover,which in observation group were significantly higher than those in control group(P<0.05).There was significant difference in clinical efficacy distribution between the two groups(P<0.05),and the total effective rate in observation group was significantly higher than that in control group(P<0.05).Before treatment there were no significant differences in airway resistance and lung compliance between the two groups(P>0.05).After treatment,the airway resistance in both groups was significantly decreased(P<0.05),however,the lung compliance was significantly increased(P<0.05),moreover,the airway resistance in observation group was significantly lower than that in control group(P<0.05),and lung compliance was significantly higher than that in control group(P<0.05).There was no significant difference in incidence rate of a
作者
张鹏
刘莉
刘保山
ZHANG Peng;LIU Li;LIU Baoshan(Department of Respiratory Diseases,Beijing Jiangong Hospital,Beijing 100032, China)
出处
《河北医药》
CAS
2021年第5期730-732,736,共4页
Hebei Medical Journal
关键词
N-乙酰半胱氨酸
布地奈德
急性加重阻塞性肺疾病
气道高反应性
N-acetylcysteine
budesonide
acute exacerbation of chronic obstructive pulmonary disease
airway hyperreactivity
