摘要
目的分析比较2008年和2018年广州市1~59岁HBV易感人群的流行病学特征,评价免疫策略效果。方法采用二阶段整群抽样法,于2008年和2018年在广州市随机抽取1~59岁常住人口进行乙肝血清流行病学调查。结果2008年和2018年调查显示,广州市1~59岁人群中HBV易感率分别为17.34%(95%CI:16.29%~18.39%)和19.77%(95%CI:18.54%~21.01%),7~16岁人群易感率(2008年23.93%,2018年36.22%)较其他年龄组高。广州市1~59岁人群中单项HBcAb阳性率分别为6.63%(95%CI:5.94%~7.33%)和2.76%(95%CI:1.62%~3.91%),下降(58.34%)。有乙肝疫苗免疫史人群单项HBcAb阳性率降幅达81.73%。结论对易感人群,包括单项HBcAb阳性成年人补种、加强或重新接种乙肝疫苗,提高人群免疫水平,降低易感性。
Objective To compare the epidemiological characteristics of hepatitis B virus susceptible population aged 1-59 in Guangzhou in 2008 and 2018, and to evaluate the effect of immunization strategy. Methods A two-stage cluster sampling method was used to conduct the seroepidemiological survey of hepatitis B among permanent residents aged 1-59 in Guangzhou in 2008 and 2018. Results In the two surveys the prevalence rates of HBV susceptibility were 17.34%(95% CI:16.29%-18.39%) and 19.77%(95% CI: 18.54%-21.01%) among the population aged 1 to 59 years, and were 23.93% and 36.22% among the population aged 7 to 16 years. The prevalence rates of single anti-HBc positivity were 6.63%(95% CI: 5.94%-7.33%) and 2.76%(95% CI: 1.62%-3.91%) in two surveys among the population aged 1 to 59 years, the difference was statistically significant. The positive rate of single anti-HBc decreased by 81.73% in the population with history of hepatitis B vaccine immunization. Conclusions Efforts should be made to strengthen the implementation of catch-up vaccination, booster vaccination and revaccination in susceptible population, including the single anti-HBc positive population.
作者
鲁影
黄勇
汪慧
杨琼英
张周斌
张春焕
LU Ying;HUANG Yong;WANG Hui;YANG Qiong-ying;ZHANG Zhou-bin;ZHANG Chun-huan(Department of Infectious Disease,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China;Department of Immunization Planning,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China;Department of Health and Education,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China;irector's Office,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2021年第3期341-345,共5页
Chinese Journal of Disease Control & Prevention
基金
广州市医学重点学科建设项目(2017-2019-07)
广州市科技项目(201804010191)。
关键词
肝炎
血清流行病学
易感
乙型肝炎病毒核心抗体
乙型肝炎疫苗
Hepatitis
Seroepidemiology
Disease susceptibility
Hepatitis B core antibody
Hepatitis B vaccine
