摘要
目的分析一起2019新型冠状病毒(2019-nCoV)无症状感染者导致家庭聚集发病的事件,探讨有效隔离各类传染源对控制病毒播散的重要性,为新型冠状病毒感染疫情防控策略的进一步完善提供参考。方法对宁夏地区发生的一起COVID-19家庭夫妇2人聚集性发病患者的发病过程、流行病学接触史等影响因素开展流行病学调查,对密切接触者进行医学隔离观察,并采集咽拭子标本进行病原学检测、胸部CT观察有无肺炎表现。结果夫妇2人发病前14天无武汉市及周边地区或其他有病例报告社区的旅行史或居住史;发病前14天内未接触过COVID-19确诊患者;未接触过来自武汉及周边地区或有病例报告社区的有发热或呼吸道症状的患者。病例1发病前4天、病例2发病前6天与居住在武汉返回宁夏的女儿一起生活,其女儿无症状,第一次核酸检测阴性,但隔离观察期间再次核酸检测阳性而被确诊。其他密切接触的48人均无可疑流行病学史,14天医学观察中无人发病,核酸检测阴性、胸部CT无异常。结论详尽的流行病学调查、管理传染源是切断病毒传播的关键;无症状感染者可以作为传染源导致COVID-19的传播,因无症状易被忽视,应引起足够的重视。
Objective To investigate the epidemiological history of a family cluster of 2019 corona virus disease(COVID-19)caused by an asymptomatic patient and analyze the importance of effective isolation of various infection sources to control the spread of disease.And to provides reference for further improvement of prevention and control strategy of novel Covid-19.Methods Epidemiological investigation was carried out on the course of onset,contact history and other influencing factors of a familial cluster of COVID-19 in Ningxia.The close contacts were isolated for medical observation.The throat swab samples were collected for etiological detection and chest CTs were carried to observe whether there was pneumonia.Results The couple had no travel or residence history in Wuhan and its surrounding areas or other community with COVID-19 case reports within 14 days before the onset of the disease.They had no contact with COVID-19 patients within 14 days before the onset of the disease.They had no contact with patients with fever or respiratory symptoms from Wuhan and surrounding areas or case reporting communities.Case one and case two had lived with their daughter who lived in Wuhan and returned to Ningxia for four days and six days respectively before the onset of the disease.The daughter was asymptomatic and the first nucleic acid test was negative,but the diagnosis was confirmed by positive nucleic acid test again during isolation observation.No suspicious epidemiological histories were found,the nucleic acid tests were negative and chest CTs were normal in 48 other close contacts.Conclusion Detailed epidemiological investigation and management of the source of infection are the key to cut off the spread of the virus.Asymptomatic infection can cause the spread of COVID-19 as the source of infection.It is easy to be ignored because of no symptoms.That should arouse enough attention.
作者
张淑香
纳建荣
刘伯飞
杨蔚
周玮
ZHANG Shuxiang;NA Jianrong;LIU Bofei;YANG Wei;ZHOU Wei(Department of Respiratory and Critical Care Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Radiology,The Fourth People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750021,China;Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2021年第3期255-258,F0003,共5页
Ningxia Medical Journal
基金
宁夏回族自治区重点研发计划科技支撑项目(2020BEG003004)。
