摘要
目的观察青光眼滤过手术结束时球结膜下注射康柏西普眼用注射液抑制滤过通道瘢痕化的作用。方法观察原发性慢性闭角型青光眼和原发性开角型青光眼的患者60例(60眼),最终完成随访12个月患者40例(40眼),其中研究组21例(21眼)、对照组19例(19眼)。分别观察术后1周、1、3、6及12个月时眼压、滤过泡高度、范围、充血程度、术后并发症。结果研究组与对照组比较术后6个月、12个月眼压更低(P<0.05)。术后1、3、6、12个月研究组滤过泡垂直高度(H)及术后1周、6、12个月研究组滤过泡水平范围(E)均大于对照组,2组比较差异有统计学意义(P<0.05)。12个月时研究组功能性滤过泡18例(86%),对照组则为15例(79%),2组比较无统计学意义(P>0.05)。2组术后并发症结膜伤口漏、角膜上皮损伤、前房出血、浅前房、滤过道内口阻塞比较无统计学意义(P>0.05),2组均未出现脉络膜脱离、前房炎症、眼内炎及全身不良反应。结论青光眼滤过手术结束时手术部位球结膜下注射康柏西普眼用注射液可以联合抑制滤过通道瘢痕化,维持功能性滤过泡,是安全、有效的治疗方法。
Objective To observe the effect of subconjunctival injection of Conbercept ophthalmic injection at the end of glaucoma filtering surgery to inhibit the scarring of the filtering channel.Methods A total of 60 patients(60 eyes)with primary chronic angle-closure glaucoma and primary open-angle glaucoma were enrolled this study,and finally 40 patients(40 Eyes)had completed in this experiment.There were 21 patients in the study group and 19 patients in the control group.The intraocular pressure,the height and range of the filtering bleb,the degree of hyperemia,and postoperative complications were observed at one week,one month,three months,six months and 12 months after the operation.Results Compared with the control group,the study group had lower intraocular pressure at six months and 12 months after surgery(P<0.05).The vertical height(H)of the filter bleb in the study group were larger than those in the control group at one month,three months,six months and 12 months after the operation.The level of the filter bleb(E)in the study group was larger than those in the control group at one month,six months and 12 months after the operation.At 12 months,there were 18 cases(86%)with functional filtering vesicles in the study group and 15 cases(79%)in the control group(P>0.05).There were no significantly differences in postoperative complications between the two groups(P>0.05).No choroidal detachment,anterior chamber inflammation,endophthalmitis,and systemic adverse reactions were observed in both groups.Conclusion Subconjunctival injection of Conbercept in the surgical site at the end of glaucoma filtering surgery can inhibit the scarring of the filtering channel and maintain the functional filtering vesicles.
作者
段敏
哈少平
何利东
庞麟
李春花
DUAN Min;HA Shaoping;HE Lidong;PANG Lin;LI Chunhua(Ophthalmic Hospital,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;The First Affiliated Hospital of Northwest Minzu University,Yinchuan 750002,China)
出处
《宁夏医学杂志》
CAS
2021年第3期206-209,共4页
Ningxia Medical Journal
基金
宁夏回族自治区自然科学基金(NZ17279)
