摘要
目的:探讨血清可溶性生长刺激表达基因2蛋白(soluble growth stimulation expressed gene 2 protein,sST2)水平与冠状动脉复杂病变及其严重程度之间的关系。方法:纳入连续住院的择期行选择性冠状动脉造影的患者共430名,依据冠状动脉造影结果分为对照组(非冠心病组,136例)、冠心病简单病变组(86例)、冠心病复杂病变组(根据Syntax评分进一步分为低危组139例、中危组36例和高危组33例)。留取空腹外周静脉血标本,采用酶联免疫吸附试验(ELISA)法分别测定上述各组患者血清可溶性ST2水平,Spearman相关性分析显示可溶性ST2水平与冠状动脉复杂病变严重程度之间的相关性。结果:在430例研究对象中,全部冠心病患者(含简单病变和复杂病变)的可溶性ST2水平明显高于对照组[(3449±1250)vs.(2743±961)pg/mL,P<0.001];冠状动脉简单病变组、复杂病变低危组、中危组、高危组患者sST2水平分别为(3200±1406)、(3338±1064)、(3728±1228)和(4261±1235)pg/mL,sST2组间差异有统计学意义(P<0.001)。Logistic回归分析显示,sST2与冠心病独立相关(OR为1.001,P<0.001),sST2与冠状动脉复杂病变的严重程度也独立相关(OR为1.001,P<0.001)。Spearman相关性分析显示:sST2表达水平与冠状动脉病变严重程度呈正相关(rs:0.543,P<0.001)。ROC曲线显示:sST2对冠状动脉复杂病变曲线下面积AUC为0.726。结论:血清可溶性ST2水平可能是冠状动脉复杂病变的重要预测指标。
AIM:To investigate the relationship between serum soluble growth stimulation expressed gene 2 protein(sST2)level and coronary artery complex lesions and their severity.METHODS:A total of 430 patients,who were sequentially admitted to hospital for selective coronary artery angiography,were divided into control group(non-coronary heart disease group,136 patients),simple lesions group of coronary heart disease(86 patients),complex lesions group(208 patients).To quantitative evaluate the complexity of coronary artery lesions,Syntax scores were further performed on patients in complex lesions groups,including 139 patients in the low-risk group,36 patients in the medium-risk group,and 33 patients in the high-risk group.The serum soluble ST2 level of each group of patients was tested by means of ELISA.Spearman correlation analysis was used for the correlation between the level of soluble ST2 and the severity of coronary complex lesions.RESULTS:In 430 subjects,the soluble ST2 level of all patients with coronary heart disease(including simple lesions and complex lesions)was significantly higher than that of the control group[(3449±1250)vs.(2743±961)pg/mL,P<0.001];the sST2 levels of patients in the coronary artery simple lesions group,complex lesions low-risk group,medium-risk group and high-risk group were(3200±1406),(3338±1064),(3728±1228)and(4261±1235)pg/mL respectively,and the differences of sST2 levels among above four groups were statistically significant(P<0.001).Logistic regression analysis showed that sST2 was independently associated with coronary heart disease(OR=1.001,P<0.001)and sST2 was independently associated with the severity of coronary artery complex lesions(OR=1.001,P<0.001).Spearman-related analysis shows that the expression levels of sST2 are positively related to the severity of coronary artery lesions(rs:0.543,P<0.001).The ROC curve showed that the area under the curve of sST2 for complex coronary lesions was AUC=0.726.CONCLUSION:Serum soluble ST2 level may be an important predictor of complic
作者
方秋珏
王昭军
袁伟
丁澍
王中群
FANG Qiujue;WANG Zhaojun;YUAN Wei;DING Shu;WANG Zhongqun(Department of Cardiology,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,Jiangsu,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2021年第3期278-284,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
镇江市科技创新资金项目(SS2018008)
镇江市社会发展重点项目(SH2015029)
镇江市社会发展重点项目(SH2019072)。
