摘要
目的分析探讨应用丙戊酸钠治疗神经内科癫痫的临床治疗效果。方法选择该院于2018年9月—2019年9月间该院收治的神经内科癫痫患者108例作为研究对象,按照随机分组法将所有患者平均分为常规组及治疗组,每组54例,其中治疗组患者行丙戊酸钠治疗,常规组患者行卡马地平治疗,比较分析两组患者的治疗总有效率及不良反应发生率。结果经治疗后,治疗组患者显效25例、有效26例、无效3例,治疗总有效率为94.4%,常规组患者显效16例、有效24例、无效14例,治疗总有效率为74.1%,差异有统计学意义(χ^(2)=8.447,P<0.05);治疗组患者出现嗜睡1例、胃肠道反应1例,不良反应发生率为3.7%,常规组患者嗜睡4例、胃肠道反应3例体质下降2例,不良反应发生率为16.7%,差异有统计学意义(χ^(2)=4.960,P<0.05)。结论相对于常规的卡马西平治疗,应用丙戊酸钠治疗神经内科癫痫能够取得良好的治疗效果,明显缓解患者的临床症状,显著减少了患者不良反应的发生率,安全可靠,有效改善神经内科癫痫患者的生活质量。
Objective To analyze the clinical therapeutic effect of sodium valproate in the treatment of neurological epilepsy.Methods A total of 108 patients with epilepsy in the Department of Neurology admitted to the hospital from September 2018 to September 2019 were selected as the research objects.According to the randomization method,all patients were equally divided into the routine group and the treatment group,each with 54 patients,the treatment group were treated with sodium valproate,and patients in the conventional group were treated with carmadipine.The total effective rate of treatment and the incidence of adverse reactions of the two groups were compared and analyzed.Results After treatment,25 patients in the treatment group were markedly effective,26 were effective,and 3 were ineffective.The total effective rate of treatment was 94.4%.In the conventional group,16 patients were markedly effective,24 were effective,and 14 were ineffective.The total effective rate was 74.1%,and the difference was statistically significant(χ^(2)=8.447,P<0.05);1 patient in the treatment group had drowsiness,1 case of gastrointestinal reactions,the incidence of adverse reactions was 3.7%,and 4 cases of drowsiness in the conventional group,3 cases of gastrointestinal reactions,2 cases of physical decline,the incidence of adverse reactions was 16.7%,and the difference was statistically significant(χ^(2)=4.960,P<0.05).Conclusion Compared with the conventional carbamazepine treatment,the application of sodium valproate in the treatment of neurological epilepsy can achieve good therapeutic effects,significantly alleviate the clinical symptoms of patients,and significantly reduce the incidence of adverse reactions in patients,safe and reliable,and effective in improving nerves quality of life of patients with internal medicine epilepsy deserves.
作者
赵立娟
潘宝军
魏象东
魏君如
ZHAO Li-juan;PAN Bao-jun;WEI Xiang-dong;WEI Jun-ru(Department of Neurology,Changle County People's Hospital,Weifang,Shandong Province,262400 China)
出处
《系统医学》
2021年第1期80-82,共3页
Systems Medicine
关键词
丙戊酸钠
神经内科癫痫
临床疗效
不良反应
Sodium valproate
Neurology epilepsy
Clinical efficacy
Adverse reactions
