摘要
睾丸间质干细胞(stem leydig cells,SLCs)是位于睾丸组织生精小管外侧壁的一类成体干细胞,具有维持自我更新和分化的特征。其分化形成的成熟间质细胞(adult leydig cells,ALCs)可以大量合成和分泌睾酮,是雄性动物机体睾酮产生的主要来源,广泛参与雄性动物的生殖和生理调控。由于SLCs发现较晚,在特异性标记及潜在调控机制和临床应用等方面的研究还并不深入。该文主要对SLCs的起源、分子标记、自我增殖和分化机制以及临床应用等进行综述,以促进SLCs研究和为雄性激素缺乏所引起疾病的临床应用奠定基础。
SLCs(stem leydig cells)are a kind of adult stem cells,located in the lateral wall of seminiferous tubules in testicular tissue.They maintain the balance of self-renewal and differentiation.ALCs(adult leydig cells)differentiated from SLCs can synthesize and secrete large amounts of testosterone which are the main source of testosterone production in male animals.ALCs are widely involved in the regulation of reproduction and physiology in the male animals.Due to the late discovery of SLCs,studies on specific markers,potential regulatory mechanism and clinical application are not in-depth.In this paper,the origin,molecular markers,self-renewal,differentiation mechanism and clinical application of SLCs will be reviewed,so as to promote the study of SLCs and the clinical application of SLCs in the treatment of diseases caused by androgens deficiency.
作者
杨镁楹
杜艺彤
陈慧芳
黄绮亮
白银山
YANG Meiying;DU Yitong;CHEN Huifang;HUANG Qiliang;BAI Yinshan(School of Life Science and Engineering,Foshan University,Foshan 528231,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2021年第1期55-62,共8页
Chinese Journal of Cell Biology
基金
广东省畜禽疫病防治研究重点实验室基金(批准号:YDWS1902)
佛山科学技术学院高层次人才启动项目(批准号:gg040969)资助的课题。
关键词
睾丸间质干细胞
睾酮
分子标记
增殖和分化
stem leydig cells
testosterone
molecular markers
proliferation and differentiation
