摘要
哺乳动物的早期胚胎发育和干细胞多能性由转录因子构成的基因网络所调控。2003年,在胚胎干细胞中发现的重要转录因子NANOG位于基因网络调控中心,对胚胎第二次命运决定和基态多能性的建立至关重要。该文将在NANOG生物学特征的基础上,重点讨论其在早期胚胎发育、胚胎干细胞与诱导性多能干细胞中的功能。
Early embryonic development and stem cell pluripotency in mammals are regulated by gene-regulatory networks of transcription factors.The master transcription factor NANOG,that is found in embryonic stem cells in 2003 is the central transcription factor in gene-regulatory networks and is crucial for the second lineage segregation and establishment of ground-state pluripotency.Based on the biological characteristics of NANOG,the paper summarizes the functions of NANOG in early embryonic development,embryonic stem cells and induced pluripotent stem cells.
作者
柴壮
刘忠华
CHAI Zhuang;LIU Zhonghua(College of Life Science,Northeast Agricultural University,Harbin 150030,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2021年第1期19-24,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金面上项目(批准号:31872360)
科技部重点研发项目(批准号:2016YFA0100200)资助的课题。
