摘要
目的了解抗磷脂综合征(APS)伴复发性流产(RM)发病的危险因素。方法选择2016年1月至2018年1月在北京大学第三医院妇产科生殖医学中心就诊的88例APS伴RM患者作为APS伴RM组,选择同期205例在北京大学第三医院产科住院分娩且无自然流产史者作为正常对照组,采用病例对照研究及流行病学调查的方法研究APS伴RM患者的潜在病因及诱发因素。结果两组年龄、女方体质指数、血型、女方工作时间、女方物理因素暴露史、男女双方饮酒、男方家族史比例及既往妊娠次数比较差异无统计学意义(P>0.05)。APS伴RM组低文化程度、低收入水平、女方化学物品暴露史、男方吸烟、女方吸烟或被动吸烟、女方RM家族史比例均高于正常对照组[11.4%(10/88)比1.0%(2/205)、18.2%(16/88)比2.4%(5/205)、6.8%(6/88)比0.9%(2/205)、28.4%(25/88)比16.1%(33/205)、29.6%(26/88)比15.6%(32/205)、7.5%(7/88)比1.5%(3/205)](P<0.05或P<0.01),且APS伴RM组女方使用电脑时间长于正常对照组[(7.49±2.56)h比(5.08±3.31)h](P<0.05)。Logistic回归分析显示,男方吸烟(OR=1.966,95%CI 1.009~3.830)、女方吸烟或被动吸烟(OR=2.498,95%CI1.332~4.685)、女方RM家族史(OR=1.875,95%CI 0.926~6.337)是APS伴RM的独立危险因素(P<0.05)。结论男方吸烟、女方吸烟或被动吸烟、女方RM家族史可能是APS伴RM的独立危险因素。
Objective To investigate the risk factors of recurrent miscarriage(RM)with antiphospholipid syndrome(APS).Methods 88 cases of APS with RM in Center for Reproductive Medicine,Department of Obstetrics and Gynecology of the Third Hospital of Peking University from Jan.2016 to Jan.2018 were included as an APS with RM group,and 205 patients who delivered in Department of Obstetrics of Peking University Third Hospital without history of spontaneous abortion were included as a normal control group.The potential causes and inducing factors of APS with RM were studied by case-control study and epidemiological investigation.Results There were no significant differences in age,female body mass index,blood type,working time,physical factor exposure history,female and male side drinking,male family history and previous pregnancy times between the two groups(P>0.05).The proportions of low education level,low income level,female chemical exposure history,male smoking,female smoking or passive smoking,and female family RM history in the APS with RM group were higher than those in the normal control group[11.4%(10/88)vs 1.0%(2/205),18.2%(16/88)vs 2.4%(5/205),6.8%(6/88)vs 0.9%(2/205),28.4%(25/88)vs 16.1%(33/205),29.6%(26/88)vs 15.6%(32/205),7.5%(7/88)vs 1.5%(3/205)](P<0.05 or P<0.01),and the time of using computer in the APS with RM group was longer than that in the normal control group[(7.49±2.56)h vs(5.08±3.31)h](P<0.05).Logistic regression analysis showed that male smoking(OR=1.966,95%CI 1.009-3.830),female smoking or passive smoking(OR=2.498,95%CI 1.332-4.685)and female RM family history(OR=1.875,95%CI 0.926-6.337)were independent risk factors for APS with RM(P<0.05).Conclusion Male smoking,female smoking or passive smoking,female RM family history may be the independent risk factors of APS with RM.
作者
徐仰英
李莉
宋钰
王海燕
XU Yangying;LI Li;SONG Yu;WANG Haiyan(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China)
出处
《医学综述》
CAS
2021年第6期1205-1209,共5页
Medical Recapitulate
基金
国家科技重大专项课题(2017ZX09304012-012)。
关键词
复发性流产
抗磷脂综合征
病例对照
危险因素
Recurrent miscarriage
Antiphospholipid syndrome
Case control study
Risk factor
