摘要
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的临床疾病,发病率随着年龄的增长而升高。OSAHS的特征是慢性间歇性缺氧和睡眠破碎,长期可导致多器官、多系统功能障碍。认知障碍是OSAHS的并发症之一,可在一定程度上降低人们的生活质量。认知障碍与OSAHS之间存在共同的发病机制,且临床上许多相关生物标志物的表达水平均升高。这些生物标志物可能识别认知障碍以及OSAHS。将生物标志物进行组合检测有利于疾病的早期诊断。未来还需要进行大量纵向队列研究,以确定OSAHS伴认知障碍的特定生物标志物。
Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common clinical disease,and its incidence increases with age.It is characterized by chronic intermittent hypoxia and sleep disruption,which can lead to multi-organ multi-system dysfunction in the long term.As one of the complications of OSAHS,cognitive impairment reduces the quality of life to a certain extent.There is a common pathogenesis between cognitive impairment and OSAHS,and the expression levels of many related clinical biomarkers are elevated,which may be used to identify cognitive impairment and OSAHS.The combined detection of biomarkers is beneficial to the early diagnosis of the diseases.In the future,a large number of longitudinal cohort studies are needed to determine the specific biomarkers of OSAHS with cognitive impairment.
作者
陈炳利
李颖慧
何欣
吴碧华
CHEN Bingli;LI Yinghui;HE Xin;WU Bihua(Department of Geriatrics,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)
出处
《医学综述》
CAS
2021年第6期1189-1193,1199,共6页
Medical Recapitulate
