摘要
抑郁障碍由于病因不明及药物治疗的有限性,导致其在医疗、社会及经济上成为一个棘手问题.表观遗传调控在神经系统发育及精神疾病中起着重要作用,近年来许多动物应激模型证实在大脑特定区域存在某些组蛋白去乙酰化酶表达异常,从而产生抑郁样行为.组蛋白去乙酰化酶抑制剂作为表观遗传调控的药物能够调节基因转录,被证实能产生一定的抗抑郁效应.本文就组蛋白去乙酰化酶及其抑制剂在抑郁障碍中的研究进行综述,旨在为治疗抑郁障碍提供更广阔的选择.
Depressive disorder is a serious medical,public and economic problem because of its unknown etiology and limitation of drug treatment.Epigenetic regulation plays an important role both in neural development and psychiatric disorders.In recent years many stress animal models identified abnormal expression of some histone deacetylases in particular brain regions which lead to depression-like behaviors.Histone deacetylase inhibitors,as a kind of epigenetic regulatory drugs,can regulate gene transcription,thus have antidepressant effect.This paper reviews the research progress of histone deacetylase and its inhibitors in depressive disorder and provides a wider range of options for the treatment of depressive disorder.
作者
任少宇
刘嘉颖
Ren Shaoyu;Liu Jiaying(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《神经疾病与精神卫生》
2020年第12期880-885,共6页
Journal of Neuroscience and Mental Health
关键词
抑郁障碍
组蛋白去乙酰化酶
应激模型
抗抑郁药
Depressive disorder
Histone deacetylases(HDAC)
Stress model
Antidepressant
