摘要
目的 评价计算机辅助认知矫正对精神分裂症患者的疗效.方法 检索PubMed、Web of Science、Cochrane library、中国学术期刊全文数据库、维普中国科技期刊数据库、万方数据医药期刊库等资源,收集计算机辅助认知矫正对精神分裂症患者康复疗效的随机对照试验,检索时限均为建库至2020年9月.采用RavMan 5.3软件进行统计处理.结果 共纳入文献18篇.Meta分析显示,计算机辅助认知矫正能缓解精神分裂症患者的精神病性症状(阳性症状95%CI:-2.34^-0.03,P=0.04;阴性症状95%CI:-2.98^-1.97,P<0.01;一般精神病性症状95%CI:-2.07^-1.25,P<0.01;整体症状95%CI:-6.59^-0.86,P=0.01),提高患者生活质量与社会功能(生活质量:95%CI:0.15~1.35,P=0.01;社会功能95%CI:0.20~1.37,P<0.01),但在改善人际关系和工作等方面的疗效,与对照组比较,差异均无统计学意义(人际关系95%CI:-0.25~0.81,P=0.30;工作95%CI:-0.62~0.18,P=0.28).结论 计算机辅助认知矫正对缓解精神分裂症患者的精神病性症状、提高生活质量、增强社会功能有积极疗效,但对人际关系与工作等的具体疗效仍需进一步研究.
Objective To evaluate the effects of computerized-assisted cognitive remediation therapy on patients with schizophrenia.Methods Randomized controlled trials(RCT)on computerized-assisted cognitive remediation therapy in the rehabilitation of patients with schizophrenia were searched for from databases such as PubMed,Web of Science,Cochrane Library,China academic journal full text database,VIP China Science and technology journal database,Wanfang Data medical journal database and other resources,with a time limit from establishment of the database to September 2020.Data were analyzed with RevMan 5.3 software.Results A total of 18 RCTs were included.The results of meta-analysis showed that computerizedassisted cognitive remediation therapy significantly relieved the symptoms[positive symptoms:95%CI(-2.34--0.03),P=0.04;negative symptoms:95%CI(-2.98--1.97),P<0.01;general psychotic symptoms:95%CI(-2.07--1.25),P<0.01;overall symptoms:95%CI(-6.59--0.86),P=0.01],also improved quality of life and social function[quality of life:95%CI(0.15-1.35),P=0.01;social function:95%CI(0.20-1.37),P=0.009].However,the results of enhancing interpersonal relationship and working ability were not statistically significant[interpersonal relationship:95%CI(-0.25-0.81),P=0.30;working ability:95%CI(-0.62-0.18),P=0.28].Conclusions Computerized-assisted cognitive remediation therapy has positive effects on relieving the psychiatric symptoms,improving the quality of life,and enhancing social functions on patients with schizophrenia,but the effects on interpersonal relationships and working ability still need further study.
作者
王筱筱
曹香
张燕红
钱瑞莲
Wang Xiaoxiao;Cao Xiang;Zhang Yanhong;Qian Ruilian(Nursing Department,Nanjing Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China;Department of PsychiatryⅡ,Nanjing Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)
出处
《神经疾病与精神卫生》
2020年第12期861-869,共9页
Journal of Neuroscience and Mental Health
关键词
精神分裂症
计算机辅助认知矫正
症状
生活质量
社会功能
Schizophrenia
Computerized-assisted cognitive remediation therapy
Symptoms
Quality of life
Social function
