摘要
目的研究冠心病(CHD)患者血清白介素-6(IL-6)、白介素-17(IL-17)及可溶性细胞间黏附因子-1(sICAM-1)水平与幽门螺旋杆菌(Hp)检测结果间的相关性,并探讨其可能机制。方法纳入2016年1月~2019年1月我院收治的74例CHD患者为研究对象,另选取同期于我院行健康体检的50例同龄体检者作为健康对照组。观察Hp感染与患者病变支数、斑块性质间的关系,并比较Hp阳性与阴性CHD患者血清IL-6、IL-17、sICAM-1水平。结果冠心病患者Hp感染率显著高于健康对照组(P<0.05),动脉狭窄支数以及颈动脉斑块性质与健康对照组比较差异具有统计学意义(P<0.05),血清IL-6、IL-17及sICAM-1水平显著高于健康对照组(P<0.05)。随着狭窄支数的增多,冠心病患者Hp阳性率显著上升(P<0.05),且血清IL-6、IL-17及sICAM-1水平也呈依次上升趋势,组间比较差异具有统计学意义(P<0.05)。存在颈动脉斑块的冠心病患者Hp阳性率显著高于无斑块者(P<0.05),不稳定斑块者Hp阳性率显著高于稳定斑块者(P<0.05)。无斑块、稳定斑块及不稳定斑块冠心病患者血清IL-6、IL-17及sICAM-1水平呈依次上升趋势(P<0.05)比较Hp阳性组冠心病患者血清IL-6、IL17及sICAM-1水平显著高于Hp阴性组(P<0.05)。结论Hp感染可能通过加剧机体炎症反应参与CHD进程,其与CHD患者动脉狭窄支数及斑块稳定性存在密切关系。
Objective To study the correlation between serum levels of interleukin-6(IL-6),interleukin-17(IL-17)and soluble intercellular adhesion factor-1(sICAM-1)and detection results of Helicobacter pylori(Hp)in patients with coronary heart disease(CHD)and analyze the possible mechanism.Methods A total of 74 patients with CHD admitted to the hospital from January 2016 to January 2019 were enrolled in the study.The relationship between Hp infection and lesion count and plaque nature was observed.The levels of serum IL-6,IL-17 and sICAM-1 were compared among CHD patients with positive Hp or negative Hp.Results The Hp infection rate of patients with coronary heart disease was significantly higher than that of healthy control group(P<0.05).The arterial stenosis count and carotid plaque nature were significantly different from those in ealthy control group(P<0.05).The levels of serum IL-6,IL-17 and sICAM-1 were significantly higher than those in healthy control group(P<0.05).With the increase of stenosis count,the Hp positive rate in patients with coronary heart disease was increased significantly(P<0.05),and the levels of serum IL-6,IL-17 and sICAM-1 were also increased in turn(P<0.05).The Hp positive rate in patients with coronary artery disease with carotid plaque was significantly higher than that of patients without plaque(P<0.05).The Hp positive rate in unstable plaque was significantly higher than that in stable plaque(P<0.05).The levels of serum IL-6,IL-17 and sICAM-1 in patients with no plaque,stable plaque and unstable plaque were increased in turn(P<0.05).The levels of serum IL-6,IL17 and sICAM-1 in Hp positive group were significantly higher than those in Hp negative group(P<0.05).Conclusion HP infection may participate in the process of CHD by aggravating the inflammatory reaction,which is closely related to the number of artery stenosis and plaque stability.
作者
邸云峰
李德才
张大勇
李双菲
王志琴
DI Yunfeng;LI Decai;ZHANG Dayong;LI Shuangfei;WANG Zhiqin(Department of Cardiology, Mianyang 404 Hospital, Mianyang 621000, Sichuan, China)
出处
《西部医学》
2021年第3期396-399,405,共5页
Medical Journal of West China
基金
四川省卫生和计划委员会科研课题(17PJ019)。
关键词
冠心病
幽门螺旋杆菌感染
炎症因子
相关性研究
冠脉病变程度
Coronary heart disease
Helicobacter pylori infection
Inflammatory factors
Correlation study
Severity of coronary artery lesions
