摘要
目的探讨乌拉地尔联合硝苯地平对妊娠期高血压患者乙酰肝素酶(HPA)、晚期糖基化终末产物(AGEs)及母婴结局的影响。方法选择2017年10月~2018年10月陕西省人民医院收治的妊娠期高血压患者200例进行研究,以简单随机分组法分为观察组(n=105)和对照组(n=95)。对照组给予硝苯地平治疗,观察组给予乌拉地尔联合硝苯地平治疗。比较两组患者的临床疗效、血清HPA、AGEs、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)水平、母婴结局及不良反应发生情况。结果治疗后,观察组总有效率显著高于对照组(P<0.05);治疗前,两组血清HPA、AGEs水平差异无统计学意义(P>0.05);治疗后,两组血清HPA、AGEs水平均有所改善,且观察组HPA、AGEs水平均显著低于对照组(P<0.05);治疗前,两组血压水平比较差异无统计学意义(P>0.05);治疗后,两组血压水平均有所改善,且观察组SBP、DBP、MAP水平均显著低于对照组(P<0.05);观察组新生儿死亡、窒息、产后出血及早产总发生率显著低于对照组(P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论在妊娠期高血压患者中应用乌拉地尔联合硝苯地平,可有效改善患者HPA、AGEs水平及母婴结局,且不会增加不良反应。
Objective To investigate the effect of urapidil combined with nifedipine on heparanase(HPA),advanced glycation end products(ages)and maternal and infant outcomes in patients with gestational hypertension.Methods 200 patients with gestational hypertension admitted to our hospital from October 2017 to October 2018 were selected and divided into the observation group(n=105)and the control group(n=95)by the random number table method.The control group was treated with nifedipine,while the observation group was treated with urapidil combined with nifedipine.The clinical efficacy,serum HPA,AGEs,systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)levels,maternal and child outcomes and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group(96.19%)was significantly higher than that of the control group(76.84%)(P<0.05).Before treatment,there was no significant difference in serum HPA and AGEs between the two groups.After treatment,serum HPA and AGEs levels in both groups were improved,and HPA and AGEs levels in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in blood pressure between the two groups.After treatment,blood pressure levels in both groups were improved,and SBP,DBP and MAP levels in the observation group were significantly lower than those in the control group(P<0.05).The total incidence of neonatal death,asphyxia,postpartum hemorrhage and preterm delivery in the observation group was 6.67%,significantly lower than that of the control group(38.95%),with significant differences(P<0.05).The total incidence of adverse reactions in the two groups was 14.29%and 23.16%,with no significant difference(P>0.05).Conclusion Urapidil combined with nifedipine has a significant effect in patients with gestational hypertension,which can effectively improve HPA,AGEs and maternal and infant outcomes,without increasing adverse reactio
作者
张京京
张凌燕
张晓姗
康楠
贺荣荣
ZHANG Jingjing;ZHANG Lingyan;ZHANG Xiaoshan;KANG Nan;HE Rongrong(Department of Obstetrics, Shanxi People's Hospital, Xi'an 710000, China;B-ultrasound Room, The First Affiliated Hospital of Air Force Military Medical University, Xi'an 710032, China)
出处
《西部医学》
2021年第3期388-391,共4页
Medical Journal of West China
基金
陕西省自然科学基础研究青年人才项目(2013JQ4003)。
关键词
乌拉地尔
硝苯地平
妊娠期高血压
乙酰肝素酶
晚期糖基化终末产物
母婴结局
Uradil
Nifedipine
Hypertension during pregnancy
Acetylheparinase
Maternal and infant outcomes of advanced glycation end products
