摘要
Aliphatic biodegradable polyesters have been the most widely used synthetic polymers for developing biodegradable devices as alternatives for the currently used permanent medical devices.The performances during biodegradation process play crucial roles for final realization of their functions.Because physiological and biochemical environment in vivo significantly affects biodegradation process,large numbers of studies on effects of mechanical loads on the degradation of aliphatic biodegradable polyesters have been launched during last decades.In this review article,we discussed the mechanism of biodegradation and several different mechanical loads that have been reported to affect the biodegradation process.Other physiological and biochemical factors related to mechanical loads were also discussed.The mechanical load could change the conformational strain energy and morphology to weaken the stability of the polymer.Besides,the load and pattern could accelerate the loss of intrinsic mechanical properties of polymers.This indicated that investigations into effects of mechanical loads on the degradation should be indispensable.More combination condition of mechanical loads and multiple factors should be considered in order to keep the degradation rate controllable and evaluate the degradation process in vivo accurately.Only then can the degradable devise achieve the desired effects and further expand the special applications of aliphatic biodegradable polyesters.
基金
This work was supported by the National Key Technology R&D Program(Nos.2014BAI11B02,2014BAI11B03,2012BAI18B01)
National Natural Science Foundation of China(Nos.11120101001,11421202,31370959,11572029,31470915)
National key research and development program in China(No.2016YFC1100704,2016YFC1102202,2016YFC1101100)
Beijing Nova Programme Interdisciplinary Cooperation Project(No.xxjc201616)
Key Laboratory of Advanced Materials of Ministry of Education of China(Tsinghua University),Fok Ying Tung Education Foundation(No.141039)
International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China,and the 111 Project(No.B13003).
