摘要
加速和改善骨结合过程是口腔种植领域的研究热点,电刺激成骨是其中的研究方向之一,但外源性电刺激目前还存在很多缺陷。鉴于骨本身具有压电特性,如能在钛种植体表面制备压电材料涂层,从而产生内源性电刺激来促进成骨就具有重要研究意义。BaTiO_(3)作为一种环境友好的无铅压电材料,其四方相具备压电效应,生物相容性良好,负荷条件下可以促进成骨。本研究首先利用阳极氧化技术在钛种植体表面制备了形貌和结构优化的TiO_(2)纳米管涂层,进而利用水热反应将TiO_(2)纳米管涂层转化为BaTiO_(3)涂层,通过优化实验参数并设置极限浓度探索出具有压电效应的四方相BaTiO_(3)涂层的合成条件,并进行了表面形貌、晶相等表征和分析,结合有限元分析模拟计算验证涂层颗粒压电势。期望为种植体表面改性提供新的思路和方法。
Accelerating and improving the process of osseointegration is a research hotspot of oral implantology, and electrical stimulation of osteogenesis is one of the research directions. In view of the bone’s piezoelectric properties and the defects of exogenous electrical stimulation, the application of piezoelectric materials to generate endogenous electrical stimulation for promoting osteogenesis is of great significance. As an environmental-friendly lead-free piezoelectric material, BaTiO_(3) has a piezoelectric effect in the tetragonal phase. Especially it has good biocompatibility and can promote bone formation under load conditions. Anodic oxidation technology and hydrothermal reaction was used in this research to construct a BaTiO_(3) piezoelectric coating on the titanium surface. By optimizing the experimental parameters and setting the limit concentration, the synthesis conditions of the tetragonal BaTiO_(3) coating was obtained. Meanwhile, the piezoelectric potential of coating particles was verified by finite element simulation. By modifying the surface of the dental implant, a new method to promote implant osseointegration was provided.
作者
郑亚飞
张鑫媛
王菁
张薇
刘利鹏
安维康
焦华
马楚凡
Zheng Yafei;Zhang Xinyuan;Wang Jing;Zhang Wei;Liu Lipeng;An Weikang;Jiao Hua;Ma Chufan(State Key Laboratory of Military Stomatology,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi’an 710032,China;School of Materials Science and Engineering,Xi’an University of Technology,Xi’an 710048,China)
出处
《稀有金属材料与工程》
SCIE
EI
CAS
CSCD
北大核心
2021年第2期581-587,共7页
Rare Metal Materials and Engineering
基金
国家自然科学基金(31470929,81970971)。
关键词
种植体
表面改性
压电效应
钛酸钡
四方相
implant
surface modification
piezoelectric effect
barium titanate
tetragonal phase
