摘要
目的观察补阳还五汤联合高压氧(HBO)治疗气虚血瘀型急性脑梗死(ACI)患者的临床疗效。方法选取2016年6月至2019年5月解放军联勤保障部第九○一医院收治的78例气虚血瘀型ACI患者作为研究对象,按数字表法随机分为3组:中药组、HBO组和联合组,每组26例。中药组在ACI常规治疗的基础上给予补阳还五中药汤剂治疗;HBO组在ACI常规治疗的基础上给予HBO治疗;联合组在ACI常规治疗的基础上给予补阳还五中药汤剂联合HBO治疗。治疗20 d后,对3组患者的基本临床特点、美国国立卫生院卒中量表(NIHSS)评分和中医证候积分进行统计学分析。结果3组治疗前的NIHSS评分和中医证候积分差异无统计学意义(H=0.304,P=0.859;H=0.379,P=0.827)。联合组治疗后的NIHSS评分低于中药组和HBO组(P=0.033,P=0.011)。联合组治疗后的NIHSS评分差值高于中药组和HBO组(P=0.025,P=0.003)。联合组治疗后中医证候积分低于中药组和HBO组(P=0.016,P=0.046)。联合组治疗后的中医证候积分差值高于中药组和HBO组(P=0.005,P=0.023)。联合组的总体临床疗效优于中药组和HBO组(P=0.045,P=0.010)。结论补阳还五汤联合HBO治疗ACI有协同、增效作用,值得临床推广应用。
Objective To observe the clinical effect of Buyang huanwu decoction combined with hyperbaric oxygen therapy on acute cerebral infarction(ACI)of qi deficiency and blood stasis type.Methods A total of 78 patients with acute cerebral infarction of qi deficiency and blood stasis type admitted to the 901 Hospital of CPLA from June 2016 to May 2019 were selected as study objects and randomly divided into 3 groups according to random number table method:Traditional Chinese medicine(TCM)group,HBO group,and combination group(n=26).The TCM group was treated with traditional Chinese medicine decoction on the basis of the conventional treatment of ACI;the HBO group was treated with HBO on the basis of conventional treatment of ACI;the combination group was treated with traditional Chinese medicine decoction and HBO on the basis of the conventional treatment of ACI.After 20 days of treatment,the National Institute of Health stroke scale(NIHSS)scores and TCM syndrome scores of the 3 groups were statistically analyzed according to their basic clinical characteristics.Results There were no significantly statistical differences in terms of NIHSS score or TCM syndrome score before treatment among the 3 groups(H=0.304,P=0.859;H=0.379,P=0.827).After treatment,the NIHSS score of the combination group was lower than those of the TCM group and the HBO group(P’=0.033,P’=0.011).The difference of NIHSS score after treatment in the combination group was higher than those in the TCM group and the HBO group(P’=0.025,P’=0.003).After treatment,the TCM syndrome score of the combination group was lower than those of the TCM group and the HBO group(P’=0.016,P’=0.046).After treatment,the difference of TCM syndrome score in the combination group was higher than those in the TCM group and the HBO group(P’=0.005,P’=0.023).The overall clinical efficacy of the combination group was better than those of the TCM group and the HBO group(P’=0.045,P’=0.010).Conclusion Buyang Huanwu decoction combined with hyperbaric oxygen therapy has a
作者
刘克万
刘晓薇
缪靓靓
陈程程
王可琼
刘宇星
梅厚东
梁育磊
Liu Kewan;Liu Xiaowei;Miao Liangliang;Chen Chengcheng;Wang Keqiong;Liu Yuxing;Mei Houdong;Liang Yulei(The 901 Hospital of CPLA,Hefei 230031,China)
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2020年第6期691-695,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
高压氧
补阳还五汤
急性脑梗死
Hyperbaric oxygen
Buyang Huanwu Decoction
Acute cerebral infarction
