摘要
目的探讨月见草油对肥胖型不孕女性代谢及肠道菌群的影响。方法选取2018年8月至2019年5月期间就诊的22例肥胖型不孕女性给予口服月见草油胶囊1个月,比较干预前后甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后2 h血糖(2hPBG)、空腹胰岛素(FINS)、餐后2 h胰岛素(2 hPINS)、体质量、体质量指数(BMI)、臀围、腰臀比(WHR)、体脂百分比(PBF)、肠道菌群及短链脂肪酸(SCFAs)的变化。结果22例患者应用月见草油干预后,12例患者自诉头面部脂溢、打鼾、痤疮、闭经、无排卵等症状得到改善,所有患者无排油便与其他不良反应。21例患者血脂结果显示,TG、TC、LDL-C水平下降(P值分别为0.25、0.10、0.63),HDL-C的水平升高(P=0.48),但差异均无统计学意义(P均>0.05)。14例患者血糖检测结果显示,FBG、2hPBG、FINS及2hPINS的水平无明显变化(P值分别为0.38、0.23、0.14、0.56)。9例患者人体成分分析检测结果显示,体质量、BMI、臀围、WHR、PBF的参数下降(P值分别为0.29、0.41、0.17、0.87、0.38),但差异无统计学意义(P均>0.05);腰围参数明显下降(P=0.04)。6例患者进行肠道菌群及SCFAs分析,检测结果显示,ACE、Shannon及Simpson指数无明显变化(P值分别为0.11、0.67、0.72),差异无统计学意义(P均>0.05);Chaol指数减少(P=0.01)。NMDS分析结果显示β多样性无差异。肠道菌群在门、属水平上均无特征性改变(P均>0.05)。SCFAs中仅有己酸含量减少(P=0.04)。结论月见草油可改善肥胖型不孕女性血脂水平及肥胖相关症状,用药安全、方便、价格低廉,月见草油短期干预对肠道菌群多样性、丰度及SCFAs影响较小。
Objective To explore the effects of evening primrose oil on the metabolism and intestinal flora of obese infertile women.Methods A total of 22 obese infertile women were treated with evening primrose oil capsules for one month in the Reproductive Medicine Center of General Hospital of Ningxia Medical University from August 2018 to May 2019.Triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPBG),fasting insulin(FINS),2-hour postprandial insulin(2 hPINS),body weight,body mass index(BMI),hip circumference,waist hip ratio(WHR),body fat percentage(PBF),intestinal flora and short chain fatty acids(SCFAs)were compared before and one month after intervention.Results After the intervention,12 patients complained that the symptoms of seborrhea,snoring,acne,amenorrhea and anovulation were improved.All patients had no oil discharge and other adverse reactions.The results of blood lipid test of 21 patients showed that the levels of TG,TC and LDL-C decreased(P=0.25,0.10,0.63,respectively),while the level of HDL-C increased(P=0.48),but there was no significant difference(P>0.05).Blood glucose monitoring was performed in 14 patients,and the results showed that the levels of FBG,2 hPBG,FINS and 2 hPINS had no significant changes,with no statistical differences(P=0.38,0.23,0.14,0.56,respectively).The body composition analysis of 9 patients showed that body weight,BMI,hip circumference,WHR and PBF decreased,but there were no statistical differences(P=0.29,0.41,0.17,0.87,0.38,respectively),while the waist circumference decreased significantly(P=0.04).The results of intestinal flora and SCFAs analysis in 6 patients showed that ACE,Shannon and Simpson indices had no significant changes(P=0.11,0.67,0.72,respectively),but the Chaol index decreased(P=0.01).The results of NMDS analysis showed that there was no difference inβdiversity.There was no characteristic change of intestinal flora at the level
作者
韩晓婷
于霞
董来慧
纳莉
牛艳玲
赵君利
HAN Xiaoting;YU Xia;DONG Laihui;NA Li;NIU Yanling;ZHAO Junli(Reproductive Medicine Center,General Hospital of Ningxia Medical University,Yinchuan 750004,Ningxia,China;Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education,Ningxia Medical University,Yinchuan 750004,Ningxia,China)
出处
《山东大学学报（医学版）》
CAS
北大核心
2021年第2期48-54,共7页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金(81060051)
宁夏科技惠民项目(2015KJHM08)。
关键词
月见草油
肥胖型
不孕女性
肠道菌群
Evening primrose oil
Obesity
Infertile women
Intestinal flora
