摘要
阿尔茨海默病(AD)是常见的慢性神经退行性疾病之一,主要表现为β淀粉样蛋白(Aβ)沉积、tau蛋白过度磷酸化及神经元和突触丢失等。目前已被批准的药物只能减缓症状,无法完全治愈本病。干细胞具有特殊的自我更新、增殖、分化和重新编程能力,特别是近年来开发的诱导多能干细胞(iPSCs)为AD的治疗提供了一个新的研究策略。iPSCs技术与基因编辑、3D类器官、生物材料支架相结合,产生了一种认识和治疗AD的新方法。该文就iPSCs疾病建模应用于AD发病机制研究及早期生物标志物检测、iPSCs与3D支架结合的细胞治疗,以及iPSCs应用于高通量药物筛选等方面的研究进展进行综述。
Alzheimer’s disease(AD)is one of the common chronic neurodegenerative diseases,and characterized mainly by the deposition of amyloidβ-protein(Aβ),hyperphosphorylation of tau protein,and neuronal and synaptic loss.Currently approved drugs can only alleviate the symptoms and cannot completely cure the disease.Stem cells have specific abilities of self-renewal,proliferation,differentiation and reprogramming.In particular,the induced pluripotent stem cells(iPSCs)developed in recent years have provided a new research strategy for the treatment of AD.The combination of iPSCs technology with gene editing,3D-like organs,and biomaterial scaffolds has resulted in a new approach to the recognition and treatment of AD.This review mainly summarizes the latest applications of iPSCs in AD,including the application of disease modeling in the research of pathogenesis of AD and early biomarker detection,the combination of iPSCs and 3D scaffold in cell therapy,and the application of iPSCs in high-throughput drug screening.
作者
李梦洁
章丽娜
商迎辉
黄汉昌
劳凤学
Li Meng-Jie;Zhang Li-Na;Shang Ying-Hui;Huang Han-Chang;Lao Feng-Xue(Beijing Key Laboratory of Bioactive Substances and Functional Foods,Institute of Functional Factors and Brain Sciences,Beijing Union University,Beijing 100191,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第2期193-199,共7页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(31471587)
学科定位十大前沿研究方向专项(ZK40201902)
北京联合大学研究生科研创新资助项目(YZ2020K001)。
关键词
阿尔茨海默病
诱导多能干细胞
细胞模型
细胞移植
药物筛选
Alzheimer’s disease
induced pluripotent stem cells
cell model
cell transplantation
drug screening
