摘要
目的探讨血清S-100钙结合蛋白β(S-100β)和神经元特异性烯醇化酶(NSE)对急诊脑出血患者预后的预测价值。方法选择2016年10月至2019年10月该院急诊收治的128例脑出血患者的资料进行回顾性分析。根据出院时患者的改良Rankin评分(MRS)将患者分为预后良好组(0~3分),预后不良组(4~6分)。比较两组的一般临床资料。对比两组的病理资料,进行脑出血患者预后的单因素分析及多因素分析,探讨急诊脑出血患者预后的影响因素。计算血清S-100β和NES水平对于急诊脑出血患者预后的预测价值。分析血清S-100β和NES的相关性。结果本研究中预后良好组共96例,预后不良组共32例。年龄、BMI、血清S-100β、血清NES、出血进入脑室、出血量、脑疝、糖尿病均是急诊脑出血患者预后的影响因素(OR=1.031、1.059、1.074、1.070、26.258、1.068、10.880、3.553,P<0.05)。血清S-100β和NES水平判断急诊脑出血患者预后的最佳截断值分别为209.93 ng/mL和15.46 pg/mL,约登指数分别为50.00%和38.54%。血清S-100β和NES之间呈正相关(r=0.256,P<0.05)。结论血清S-100β和NES水平能够对急诊脑出血患者的预后进行良好的预测,两种指标对于脑出血患者的病情变化具有良好的指示作用。
Objective To investigate the predictive value of serum S-100 calcium binding proteinβ(S-100β)and neuron-specific enolase(NSE)on the prognosis of patients with acute cerebral hemorrhage.Methods The data of 128 patients with cerebral hemorrhage admitted to the Department of Emergency of the hospital from October 2016 to October 2019 were selected for retrospective analysis.According to the modified Rankin score(MRS)of the patients at the time of discharge,the patients were divided into the good prognosis group(0-3 points)and the poor prognosis group(4-6 points).The general clinical data and the pathological data of the two groups were compared.Univariate analysis and multivariate analysis of the prognosis of patients with acute cerebral hemorrhage were carried out to explore the factors affecting the prognosis of patients.The predictive values of serum S-100βand NES level for the prognosis of patients with acute cerebral hemorrhage were calculate.The correlation between serum S-100βand NES were analyzed.Results In this study,96 cases were divided into the good prognosis group and 32 cases were the poor prognosis group.Age,BMI,serum S-100β,serum NES,amount of bleeding into the ventricle,amount of bleeding,brain herniation,and diabetes were all influencing factors for the prognosis of patients with acute cerebral hemorrhage(OR=1.031,1.059,1.074,1.070,26.258,1.068,10.880,3.553,P<0.05).The best cut-off values of serum S-100βand NES levels to judge the prognosis of patients with emergency cerebral hemorrhage were 209.93 ng/mL and 15.46 pg/mL,and the Youden index were 50.00%and 38.54%,respectively.There was a positive correlation between serum S-100βand NES(r=0.256,P<0.05).Conclusion Serum S-100βand NES levels can makea good prediction of the prognosis of patients with acute cerebral hemorrhage,and the two indicators have a good indication of changes in the condition of patients with cerebral hemorrhage.
作者
车鹏
黄可
胡俊
黎林果
汤道雄
CHE Peng;HUANG Ke;HU Jun;LI Linguo;TANG Daoxiong(Department of Emergency,the Third Hospital of Mianyang/Sichuan Mental Health Center,Mianyang,Sichuan 621000,China)
出处
《重庆医学》
CAS
2021年第5期757-761,共5页
Chongqing medicine
基金
2018年四川省卫生和计划生育委员会科研课题(18PJ321)。
