摘要
目的:观察益气解毒方联合美沙拉嗪肠溶片对溃疡性结肠炎患者清除氧自由基能力及热休克蛋白70(HSP70)表达的影响。方法:选取溃疡性结肠炎患者100例,采用随机数字表法分为观察组和对照组各50例。对照组给予美沙拉嗪肠溶片治疗,观察组在对照组基础上加用益气解毒方治疗。比较2组临床疗效,统计治疗前后中医证候积分,检测治疗前后超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化脂质(LPO)、HSP70、白细胞介素-17(IL-17)、白细胞介素-33(IL-33)水平。结果:观察组总有效率为94.00%,高于对照组80.00%,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分较治疗前降低,且观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组SOD、GSH-Px、LPO、HSP70、IL-17、IL-33水平比较,差异无统计学意义(P>0.05)。治疗后,2组SOD、GSH-Px、HSP70水平高于治疗前,LPO、IL-17、IL-33水平低于治疗前;且观察组SOD、GSH-Px、HSP70水平高于对照组,LPO、IL-17、IL-33水平低于对照组;差异均有统计学意义(P<0.05)。结论:益气解毒方联合美沙拉嗪肠溶片治疗溃疡性结肠炎可清除氧自由基,调节炎症因子和HSP70的表达水平,提高临床效果。
Objective:To observe the effect of Yiqi Jiedu prescription combined with mesalazine enteric-coated tablets on the ability of scavenging oxygen free radicals and the expression of heat shock protein 70(HSP70)in patients with ulcerative colitis.Methods:A total of 100 cases of patients with ulcerative colitis were selected and divided into the observation group and the control group according to the random number table method,50 cases in each group.The control group was treated with mesalazine enteric-coated tablets,and the observation group was additionally treated with Yiqi Jiedu prescription based on the treatment of the control group.The clinical effect in the two groups was compared.Before and after treatment,Chinese medicine syndrome scores were counted;the levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),lipid peroxide(LPO),HSP70,interleukin-17(IL-17)and interleukin-33(IL-33)were detected.Results:The total effective rate was 94.00%in the observation group,higher than that of 80.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of SOD,GSH-Px,LPO,HSP70,IL-17 and IL-33 between the two groups(P>0.05).After treatment,the levels of SOD,GSH-Px and HSP70 in the two groups were higher than those before treatment,and the levels of LPO,IL-17 and IL-33 were lower;the levels of SOD,GSH-Px and HSP70 in the observation group were higher than those in the control group,and the levels of LPO,IL-17 and IL-33 were lower,differences being significant(P<0.05).Conclusion:The application of Yiqi Jiedu prescription combi
作者
谭首海
于秀芝
刘海龙
王文航
TAN Shouhai;YU Xiuzhi;LIU Hailong;WANG Wenhang
出处
《新中医》
CAS
2021年第4期91-94,共4页
New Chinese Medicine
关键词
溃疡性结肠炎
益气解毒方
美沙拉嗪肠溶片
氧自由基
热休克蛋白70
炎症因子
Ulcerative colitis
Yiqi Jiedu prescription
Mesalazine enteric-coated tablets
Oxygen free radicals
Heat shock protein 70
Inflammatory factors
