摘要
清代医家叶天士于《临证指南医案》首次提出"上下交损,当治其中"的治疗方法,用于治疗心肾不交的遗精。该治法突出了后天之本,中焦脾胃在疾病发生发展中的重要作用。中焦脾胃运化失常,可导致脑髓失养或毒损脑络,从而引起阿尔茨海默病的发生发展,现代医学研究认为阿尔茨海默病与肠道微生物群落失调密切相关。结合现代医学与传统医学的理论特点,进一步探究中焦脾胃与肠道微生物群落的相互关系。通过查阅文献、参考古籍医案、阿尔茨海默病用药规律分析、相关实验研究,为此法在临床上治疗阿尔茨海默病提供论据支持,为中医药防治阿尔茨海默病提供新思路,为中医药防治复杂病因病机的脑系疾病提供广泛的应用前景。
Ye Tianshi,a physician in Qing Dynasty,first proposed in the Guide to Clinical Practice with Medical Records the treatment method of "When the upper and the lower both impair,treat the middle jiao" for the treatment of seminal emission caused by the heart and kidney disharmony.This method highlights the important role of the spleen and stomach,the acquired foundation,in the occurrence and development of a disease.The abnormal transportation of spleen and stomach in the middle jiao can lead to dystrophy of the brain marrow or toxic damage to the brain collaterals,resulting in the occurrence and development of Alzheimer’s disease.Modern medical research suggests that Alzheimer’s disease is closely related to the imbalance of intestinal microflora.This paper aims to further explore the relationship between spleen and stomach in middle jiao and intestinal microflora by combining the theoretical characteristics of modern medicine with those of traditional medicine.By consulting literature,referring to ancient medical records,analysis of Alzheimer’s disease medication rules,and related experimental studies,this research means to provide evidence support for the clinical treatment of Alzheimer’s disease,to provide new ideas for the prevention and treatment of Alzheimer’s disease with traditional Chinese medicine,and to provide a wide range of application prospects for traditional Chinese medicine to prevent and treat brain diseases with complex etiology and pathogenesis.
作者
朱晓婷
黎明全
赵建军
ZHU Xiaoting;LI Mingquan;ZHAO Jianjun(Changchun University of Chinese Medicine,Changchun 130117,China)
出处
《吉林中医药》
2021年第2期160-163,共4页
Jilin Journal of Chinese Medicine
基金
吉林省科技厅自然科学基金项目(20160101184JC)。
关键词
上下交损
当治其中
菌群-肠-脑轴
阿尔茨海默病
脾胃
"When the upper and the lower both impair
treat the middle jiao"
flora-intestine-brain axis
Alzheimer’s disease
spleen and stomach
