摘要
目的探讨早期使用丁苯酞氯化钠注射液对急性脑梗死(ACI)并发下肢深静脉血栓(LDVT)的影响。方法连续纳入2019年5月至2020年1月我院住院治疗的208例发病时间在48 h内的ACI患者,随机分为使用丁苯酞氯化钠注射液的治疗组和未使用的对照组各104例。对照组接受ACI常规治疗,治疗组在常规治疗方案基础上予以丁苯酞氯化钠注射液治疗2周。分别对两组患者治疗前后进行NIHSS评分和mRS评分,对比两组治疗的临床疗效,并在发病后7~10 d对两组有LDVT高危风险因素的患者行下肢深静脉血管超声检查。结果两组患者治疗前NIHSS评分及mRS评分比较差异无统计学意义,治疗后两组患者NIHSS评分及mRS评分均较治疗前降低(P<0.05)。治疗后治疗组NIHSS评分及mRS评分与对照组相比明显下降(P<0.05)。治疗组总有效率优于对照组(92.31%vs.82.69%,P<0.05),且治疗组LDVT发生率明显低于对照组(22.22%vs.42.55%,P<0.05)。结论早期使用丁苯酞氯化钠注射液可以改善ACI患者的神经功能缺损症状、降低致残率,同时能减少LDVT的发生,改善预后,值得临床推广并早期应用。
Objective To investigate the effect of early applicant butylphthalide sodium chloride injection on acute cerebral infarction(ACI)complicated with deep venous thrombosis of the lower extremity(LDVT).Methods Total 208 patients with ACI who were admitted to our hospital from May 2019 to January 2020 with an onset time of less than 48 hours were included.Those who were divided into 104 patients who were treated with butylphthalide(treatment group)and 104 patients who were not treated with butylphthalide(control group).The control group was treated with routine treatment for ACI and the treatment group was treated with butylphthalide sodium chloride injection for 2 weeks on the basis of routine treatment.NIHSS scores and mRS scores were compared between the two groups before and after treatment,and the lower extremity deep vein blood vessel ultrasound examination was performed in two groups with LDVT risk factor between 7 and 10 days after the onset of the disease.Results There was no significant difference in NIHSS score and mRS score between the two groups before treatment.After treatment,the NIHSS score and mRS score were lower than before treatment(P<0.05).NIHSS score and mRS score of the treatment group after treatment were significantly lower than those of the control group(P<0.05).The total effective rate of the treatment group was better than that of the control group(92.31%vs.82.69%,P<0.05%),and the LDVT rate of the treatment group was significantly lower than that of the control group(22.22%vs.42.55%,P<0.05%).Conclusion The early use of butylphthalide sodium chloride injection can improve the neurological deficit symptoms,reduce the rate of disability in ACI patients,reduce the incidence of LDVT,improve the prognosis,it is worthy of clinical promotion and early application.
作者
刘丽沙
周慧
郭晓燕
唐兴江
Liu Lisha;Zhou Hui;Guo Xiaoyan(Department of Neurology,The Affiliated Hospital of Southwest Medical University Neurological Disease and Brain Function Laboratory,The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《四川医学》
CAS
2021年第1期53-57,共5页
Sichuan Medical Journal
关键词
急性脑梗死
下肢深静脉血栓
丁苯酞
acute cerebral infarction
deep venous thrombosis of lower extremity
butylphthalide
