摘要
DNA甲基化作为表观遗传调控机制,是疾病潜在的诊断标志物及治疗靶点,其可通过参与平滑肌细胞增殖、参与脂质形成、调控炎症反应及参与AS危险因素的形成等作用,影响动脉粥样硬化的进程。DNA甲基化的微观表象可以揭示"天人相应""阴阳自和"等中医经典理论,而中药复方及单体通过调控DNA甲基化可调节特定基因的表达,在稳定动脉斑块、增强抗凝疗效、保护血管内皮细胞等方面发挥作用,延缓及改善动脉粥样硬化的发展。
DNA methylation, as an epigenetic regulatory mechanism, is a potential diagnostic marker and therapeutic target of diseases. It can affect the process of atherosclerosis by participating in smooth muscle cell proliferation, lipid formation, regulation of inflammatory response and the formation of as risk factors. The micro appearance of DNA methylation can reveal the classical theories of traditional Chinese Medicine such as "correspondence between man and nature" and "harmony between Yin and Yang". By regulating DNA methylation, Chinese herbal compound and monomer can regulate the expression of specific genes, play a role in stabilizing arterial plaque, enhancing anticoagulant effect, protecting vascular endothelial cells and so on, and delay and improve the development of atherosclerosis.
作者
肖婷
何贵新
秦伟彬
莫霄云
林琳
邓学秋
陈天宇
任加以
玉黎燕
申永艳
XIAO Ting;HE Gui-xin;QIN Wei-bin;MO Xiao-yun;LIN Lin;DENG Xue-qiu;CHEN Tian-yu;REN Jia-yi;YU Li-yan;SHEN Yong-yan(Guangxi University of Traditional Chinese Medicine,Nanning Guangxi 530299,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning Guangxi 530022,China)
出处
《中医药导报》
2021年第2期110-114,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金地区基金项目(81960861)
广西科学重点研发计划项目(桂科AB19110006)
广西研究生教育创新计划资助项目(YCSY2020099)。
