摘要
目的探讨天麻素胶囊联合苯妥英钠片治疗三叉神经痛的临床疗效。方法选取2018年3月—2020年9月在驻马店市中心医院就诊的100例三叉神经痛患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各50例。对照组口服苯妥英钠片,100 mg/次,3次/d。治疗组在对照组的基础上口服天麻素胶囊,0.1 g/次,3次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组的临床症状、视觉模拟评分法(VAS)评分、血清5-羟色胺(5-HT)、β-内啡肽(β-EP)、前列腺素E2(PGE2)、白细胞介素-1β(IL-1β)水平。结果治疗后,治疗组患者的总有效率为94.00%,对照组的总有效率为82.00%,组间比较差异具有统计学意义(P<0.05)。治疗后,两组的发作次数、发作持续时间明显降低,差异有统计学意义(P<0.05);且治疗组发作次数、发作持续时间降低的更明显,差异有统计学意义(P<0.05)。治疗后,两组VAS评分明显降低,差异有统计学意义(P<0.05);且治疗组的VAS评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的5-HT、PGE2、IL-1β水平明显降低,β-EP水平明显升高(P<0.05);治疗后,治疗组的5-HT、PGE2、IL-1β水平低于对照组,β-EP水平高于对照组,差异有统计学意义(P<0.05)。结论天麻素胶囊联合苯妥英钠片可提高三叉神经痛的临床疗效,减轻临床症状和疼痛程度,调节神经递质的分泌,减轻神经炎症反应。
Objective To investigate the clinical effect of Gastrodin Capsules combined with Phenytoin Sodium Tablets in treatment of trigeminal neuralgia. Methods Patients(100 cases) with trigeminal neuralgia in Zhumadian Central Hospital from March 2018 to September 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Phenytoin Sodium Tablets, 100 mg/time, three times daily. Patients in the treatment group were po administered with Gastrodin Capsules on the basis of the control group, 0.1 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms, VAS scores, the serum levels of 5-HT, β-EP, PGE2, and IL-1β in two groups were compared. Results After treatment, the total effective rates were 94.00% and 82.00% in the treatment group and control group, and the difference was statistically significant(P < 0.05). After treatment, the attack frequency and attack duration of two groups were significantly reduced, and the difference was statistically significant(P < 0.05). The attack frequency and attack duration of the treatment group were significantly lower than those of the control group, and the difference was statistically significant(P < 0.05). After treatment, the VAS scores of two groups were significantly decreased, and the difference was statistically significant(P < 0.05). And the VAS score of the treatment group was significantly lower than that of the control group, with a statistically significant difference(P < 0.05). After treatment, the levels of 5-HT, PGE2, IL-1β, in two groups were significantly decreased, but the levels of β-EP in two groups were significantly increased(P < 0.05). After treatment, the levels of 5-HT, PGE2, and IL-1β in the treatment group were lower than those in the control group, but the levels of β-EP in the treatment group were higher than that in the control group, and the difference was statistic
作者
李永华
郭静华
王想
贾骏
LI Yong-hua;GUO Jing-hua;WANG Xiang;JIA Jun(Department of Stomatology,Zhumadian Central Hospital,Zhumadian 463000,China)
出处
《现代药物与临床》
CAS
2021年第1期50-53,共4页
Drugs & Clinic
基金
河南省医学科技攻关计划联合共建项目(LHGJ20191122)。
