摘要
目的探讨快速眼球运动睡眠时间与心绞痛发生率在不同性别中的相关性。方法来自睡眠心脏健康研究的2 710名参与者,其中男性1 103(40.7%)例,女性1 607(59.3%)例,平均年龄(61.7±10.9)岁。本研究根据REM睡眠时间百分比(REM%)分为1级(<20%),2级(20~25%)和3级(>25%),对所有参与者采集了完整的多导睡眠图数据和病历信息。多因素Logistic回归分析探讨REM%与心绞痛(AP)发生之间的关系。结果 REM%3组之间在年龄、体质量指数(BMI)、吸烟、呼吸暂停低通气指数(AHI)、糖尿病、高血压等方面均有不同程度差异(P<0.05)。此外,在男性和女性人群中,REM%3级患者的AP发生率显著高于1级和2级患者。在调整了年龄、种族、AHI、婚姻状况、教育程度、BMI、糖尿病、高血压和吸烟状况等因素之后,多因素Logistic回归分析显示,女性中REM%> 25%与AP密切相关(OR=1.523,95%CI:1.132~2.051,P=0.006)。结论在女性人群中,REM%>25%与AP的患病率显著相关,但在男性人群中尚未发现两者之间存在差异。
Objective To investigate the relationship between rapid eye movement sleep(REM) and the incidence of angina pectoris(AP) in different genders. Methods We recruited 2710 participants from the Sleep Heart Health Study with an average age of(61.7±10.9)y, of whom 1 103(40.7%) were male and 1 607(59.3%) were female. The participants were divided into grade 1(<20%), grade 2(20%-25%), and grade 3(>25%) according to the percentage of REM sleep time(REM%). Complete polysomnography data and medical records were collected for all the participants. Multivariate logistic regression analysis was used to characterize the independent association between REM% and the occurrence of AP. Results REM% in the three groups varied significantly in age, body mass index(BMI), smoking, AHI, diabetes, and hypertension(P<0.05). In addition, the incidence of AP in patients with grade 3 of REM% was significantly higher than those with grade 1 and 2 in both men and women. After adjusting for covariates such as age, ethnicity, AHI, marital status, education level, BMI, diabetes, hypertension, and smoking status, multiple logistic regression analysis showed that REM% >25% in women was closely related to AP(OR=1.523;95% CI:1.132-2.051, P=0.006). Conclusion Participants with REM sleep time >25% have a significantly increased prevalence of AP in women, but not in men.
作者
李会敏
闫斌
范雅娟
王崴
杨建
马现仓
LI Huimin;YAN Bin;FAN Yajuan;WANG Wei;YANG Jian;MA Xiancang(Department of Psychiatry,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2021年第2期267-271,279,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省创新人才推进计划-重点科技创新团队计划资助项目(No.2017KCT-20)。
