摘要
目的:探讨Aβ_(1-42)淀粉样蛋白及Tau蛋白水平与高原地区老年高血压患者发生轻度认知障碍的相关性。方法:收集西宁地区及玉树地区的老年高血压患者162例,以Petersen诊断标准、临床痴呆评定量表(CDR)评定患者认知情况,得分为0.5分的患者纳入轻度认知障碍(MCI)组,得分0分的患者纳入非轻度认知障碍(NMCI)组,收集所有患者临床资料、评分资料,ELISA检测患者血清中Aβ_(1-42)及Tau蛋白水平。结果:MCI组与NMCI组性别、年龄、文化程度、高血压分级、收缩压、血中Aβ_(1-42)浓度、血中Tau蛋白浓度比较,差异有统计学意义(P <0.05);Aβ_(1-42)(OR=3.881,95%CI:2.561~5.881)是发生MCI的危险因素(P <0.05)。结论:血清Aβ_(1-42)与高原老年高血压患者发生轻度认知障碍密切相关,有望应用于临床早期筛查。
Objective:This syudy is to explore the correlation between Aβ_(1-42) amyloid and Tau levels and the occurrence of mild cognitive impairment in elderly hypertensive patients at high altitude.Methods: A total of 162 elderly patients with hypertension in Xining and Yushu were divided into mild cognitive impairment(MCI) group and non-mild cognitive impairment(NMCI)group according to Petersen diagnostic criteria and CDR score scale. The clinical data and score data of all patients were collected. The levels of Aβ_(1-42) and Tau protein in serum were detected by ELISA.Results:There were significant differences in gender,age,education level,hypertensiongrade,systolic blood pressure,Aβ_(1-42) and Tau protein concentration between MCI group and NMCI group(P < 0.05).Aβ_(1-42)(OR=3.881,95%CI:2.561~5.881)was risk factors for MCI(P < 0.05).Conclusion:Serum Aβ_(1-42) and systolic blood pressure are closely related to the occurrence of mild cognitive impairment in elderly hypertensive patients at high altitude, and these two indicators are expected to be applied in clinical early screening.
作者
马君
张珺
刘景隆
梅利
王思雯
张红梅
珠扎来西
Ma Jun;Zhang Jun;Liu Jinglong;Mei Li;Wang Siwen;Zhang Hongmei;Zhazhu Laixi(Department of Geriatrics,The First people's Hospital of Xining,Xining,810000;Department of Internal Medicine,Bayi Hospital,Yushu,815000)
出处
《高原医学杂志》
CAS
2020年第3期1-5,共5页
Journal of High Altitude Medicine
基金
西宁市科技局立项科研,项目编号:2008-M-11。
