摘要
目的:了解山西省某三级甲等儿童医院2016年—2018年抗菌药物的使用情况和常见致病菌耐药性的变迁,并探讨两者之间的相关性。方法:分析2016年—2018年抗菌药物的使用频度(DDDs)和同期临床致病菌的检出、分布及耐药性变化情况,采用SPSS 24.0对抗菌药物的用量与常见致病菌耐药性进行相关性分析。结果:2016年—2018年抗菌药物总的DDDs逐年增长,2016年—2018年增长幅度为6.05%。各年度各类抗菌药物DDDs排在前6位的保持不变。3年间分离出的致病菌以革兰阴性菌为主,检出率排在前5位的分别为流感嗜血杆菌、肺炎链球菌、大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌。金黄色葡萄球菌对环丙沙星的耐药率与其DDDs呈正相关(r=0.99,P<0.05);肺炎克雷伯菌对美罗培南以及对头孢西丁的耐药率与其各自DDDs呈负相关(r值为-0.99,-0.99,P<0.05)。结论:抗菌药物DDDs与细菌耐药率之间存在一定的相关性,肺炎克雷伯菌的耐药情况较为严重,需加强对临床抗菌药物,特别是二代和三代头孢菌素类使用的管理和常见细菌耐药性的监测。
Objective:To investigate the use of antimicrobial and the change of resistance to common pathogens in a tertiary grade A children's hospital in Shanxi province from 2016 to 2018,and explore the correlation between the two.Methods:The frequency of antimicrobial use agents(DDDs)and the detection,distribution and change of resistance of common pathogens in the same period from 2016 to 2018 were analyzed.Pearson correlation analysis was conducted between the amount of antimicrobial agents and the resistance of common pathogens by using SPSS24.0.Results:The total DDDs of antibacterial drugs in the hospital increased year by year from 2016 to 2018,with an increase rate of 6.05%from 2016 to 2018.The top six of antibacterial drugs'DDDs in each year had remained unchanged.The pathogenic bacteria isolated from the hospital within three years were mainly gram⁃negative bacteria,and the top five of detection rate were haemophilus influenzae,streptococcus pneumoniae,escherichia coli,staphylococcus aureus and klebsiella pneumoniae.The resistance rate of staphylococcus aureus to ciprofloxacin was positively correlated with DDDs(r=0.99,P<0.05).The resistance rates of klebsiella pneumoniae to meropenem and cefoxitin were negatively correlated with their DDDs(r=-0.99,r=-0.99,P<0.05).Conclusions:There was a certain correlation between antimicrobial DDDs and bacterial drug resistance rate,and the drug resistance of klebsiella pneumoniae in this hospital was relatively serious.It was necessary to strengthen the management of the clinical use of antimicrobial drugs,especially the second and third generation cephalosporins,and the monitoring of the drug resistance of common bacteria.
作者
李晓禹
范惠霞
LI Xiaoyu;FAN Huixia(Shanxi Medical University,Shanxi 030001 China)
出处
《护理研究》
北大核心
2021年第5期789-795,共7页
Chinese Nursing Research
关键词
抗菌药物
致病菌
用药频率
耐药性
相关性
护理管理
antimicrobial agents
pathogenic bacteria
frequency of medication
drug resistance
correlation
nursing management
