摘要
目的:探讨紫杉醇联合奈达铂同步放疗对进展期食管癌疗效及血清癌胚抗原(CEA)、细胞角蛋白片段19(CYFRA21-1)水平的影响。方法:选取80例进展期食管癌患者,随机分为观察组与对照组,各40例。对照组接受常规放疗,观察组在对照组基础上给予奈达铂+紫杉醇同步放疗。观察记录2组治疗总有效率、中位生存期及1、2、3年生存率,同时对2组血清CEA、鳞状上皮细胞癌抗原(SCCA)、CYFRA21-1水平进行比较。结果:观察组患者治疗总有效率67.50%高于对照组的42.50%(P<0.05);2组比较,观察组患者治疗后血清CEA[(52.46±7.28)vs(86.45±10.06)ng·mL^(-1)]、SCCA[(2.21±0.36)vs(3.85±0.53)ng·mL^(-1)]、CYFRA21-1[(2.11±0.29)vs(4.53±0.68)U·mL^(-1)]水平均低于对照组(P<0.05);观察组患者3年生存率(32.50%vs 12.50%)、中位生存期[(19.91±3.21)vs(16.83±2.49)个月]高于对照组(P<0.05)。结论:紫杉醇联合奈达铂同步放疗对进展期食管癌的疗效较好,能降低患者血清CEA、SCCA、CYFRA21-1水平。
Objective:To study the curative effect of concurrent radiotherapy of paclitaxel and nedaplatin on advanced esophageal carcinoma,and its influence on serum carcinoembryonic antigen(CEA)and cytokeratin fragment 19(CYFRA21-1)levels.Methods:80 patients with advanced esophageal carcinoma were selected and randomly divided into 2 groups:observation group and control group,40 cases in each group.The control group received routine radiotherapy,while on this basis,the observation group received concurrent radiotherapy of nedaplatin and paclitaxel.The total response rates,median survival,1-year,2-year,and 3-year survival rates of the 2 groups were recorded.Meanwhile,serum CEA,squamous cell carcinoma antigen(SCCA),and CYFRA21-1 levels in the 2 groups were compared before and after treatment.Results:The total response rate in the observation group was 67.50%,significantly higher than 42.50%in the control group(P<0.05).After treatment,serum levels of CEA,SCCA,and CYFRA21-1 in the 2 groups decreased,which were significantly lower in the observation group than in the control group(P<0.05);The 3-year survival rate and median survival of the observation group were significantly better than those of the control group(P<0.05).Conclusion:Combined use of concurrent radiotherapy of paclitaxel and nedaplatin is effective in treating advanced esophageal carcinoma.Besides,it can reduce serum CEA,SCCA,and CYFRA21-1 levels.
作者
张双会
Zhang Shuanghui(Department of Cardiothoracic Surgery,First Affiliated Hospital of Henan University of Science and Technology)
出处
《长治医学院学报》
2021年第1期41-43,47,共4页
Journal of Changzhi Medical College
基金
河南省科技攻关项目(2018020889)。
关键词
紫杉醇
奈达铂
放疗
食管癌
paclitaxel
nedaplatin
radiotherapy
esophageal carcinoma
