摘要
中药与天然药物在2015~2020年取得多项突破性进展,屠呦呦青蒿素研究获得诺贝尔奖促使国内外掀起研究中药与天然药物的热潮,“甘露寡糖二酸”、“桑枝总生物碱片”等原创药物获得新药证书;多项研究成果入选年度“中国十大医学进展”,在Nature、Science、New England Journal of Medicine、Lancet等国际顶级期刊发表了高水平的研究论文,本文梳理总结了这五年期间国内外科学家在国际著名期刊发表中药与天然药物相关的亮点学术成果,并对其在化学、药物资源、药理、制剂、新药开发等相关领域取得的重要进展进行了评述,以期追踪和报道中药与天然药物领域发展的前沿和热点,并通过对其分析得出学科发展的启示和展望。
The scientific world has witnessed multiple outstanding breakthroughs in the field of traditional Chinese medicine and natural product derived drugs during 2015-2020.The research by Prof.Tu Youyou on artemisinin gained her as one of the winners of Nobel Prize in Physiology or Medicine in 2015,has also aroused profound impetus in the investigation of traditional Chinese medicine and natural product drugs.Mori ramulus alkaloids tablets and GV-971 capsules have been approved by National Medical Products Administration(NMPA)for clinical application.Some of the important research findings were selected as"Top 10 major medical advances"in China,and a plenty of research articles were accepted by world top publications such as Nature,Science,New England Journal of Medicine,as well as Lancet,etc.The current review summarized and commented on the research highlights of traditional Chinese medicine and natural drugs published in world top journals from 2015 to 2020,including the major progresses in the sub-divided areas of chemistry,molecular pharmacognosy,pharmacology and toxicology,as well as pharmaceutics.This report aims to follow and review the leading research and hot spots in fields of traditional Chinese medicine and natural drugs,and to provide prospects and inspirations in the interdisciplinary areas based on our preliminary analyses.
作者
陈士林
孙奕
万会花
张晗
赵庆贺
CHEN Shi-lin;SUN Yi;WAN Hui-hua;ZHANG Han;ZHAO Qing-he(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第12期2751-2776,共26页
Acta Pharmaceutica Sinica
基金
国家重点研发计划资助项目(2019YFC1711100).
关键词
中药
天然药
天然产物
药用植物
药理
制剂
Chinese materia medica
natural medicine
natural product
medicinal plant
pharmacology
pharmaceutics
