摘要
目的分析血清尿酸(UA)水平与脑梗死患者颅内外动脉粥样硬化性狭窄(ICAS/EAS)的关系。方法选取2019年1月—2020年1月于贵州省骨科医院随诊的脑梗死患者216例作为研究对象,根据患者有无ICAS/EAS分为狭窄组(150例)和对照组(66例),比较两组患者血清UA水平和一般临床资料,分析不同严重程度的ICAS/EAS患者血清UA水平的表达情况,分析UA水平与ICAS/EAS严重程度的相关性,探讨脑梗死患者ICAS/EAS的影响因素。结果狭窄组患者血清UA水平、年龄、体重指数(BMI)、总胆固醇(TC)水平、低密度脂蛋白(LDL)水平、高血压病比例均明显高于对照组,而血清高密度脂蛋白(HDL)水平明显低于对照组(均P<0.05)。重度、中度、轻度组UA水平高于对照组,重度、中度组UA水平高于轻度组,重度组UA水平高于中度组(均P<0.05)。Spearman相关性分析显示血清UA水平与ICAS/EAS严重程度呈明显的正相关(rs=0.634,P<0.001)。Logistic回归分析显示血清UA水平(OR=3.748)、年龄(OR=2.895)、高血压病(OR=3.024)、TC水平(OR=2.668)、LDL水平(OR=2.349)均是脑梗死患者ICAS/EAS的危险因素(均P<0.05)。结论血清UA水平可较好地反映脑梗死患者ICAS/EAS的严重程度,且其是ICAS/EAS的独立危险预测因子。
Objective To analyze the relationship between serum uric acid(UA)level and intracranial/extracranial atherosclerotic stenosis(ICAS/EAS)in patients with cerebral infarction.Methods A total of 216 patients with cerebral infarction who were followed up in Guizhou Orthopedic Hospital from January 2019 to January 2020 were selected as the research objects.According to the presence or absence of ICAS/EAS,the patients were divided into the stenosis group(150 cases)and the control group(66 cases).The differences of serum UA level and general clinical data between the two groups were compared.The expression of serum UA levels in patients with different severity of ICAS/EAS were analyzed,and the relationship between UA level and ICAS/EAS severity were analyzed,the influencing factors of ICAS/EAS in patients with cerebral infarction was explored.Results The UA level,age,body mass index(BMI),total cholesterol(TC),low density lipoprotein(LDL)and the proportion of hypertension in the stenosis group were higher than those of the control group,while the serum high density lipoprotein(HDL)level was lower than that of the control group(all P<0.05).The UA levels of severe,moderate and mild group were higher than that of the control group,the severe,moderate group were higher than that of the mild group,and the severe group was higher than that of the moderate group(all P<0.05).Spearman correlation analysis showed that serum UA level was positively correlated with ICAS/EAS severity(rs=0.634,P<0.001).Logistic regression analysis showed that UA(OR=3.748),age(OR=2.895),hypertension(OR=3.024),TC(OR=2.668),and LDL(OR=2.349)were all risk factors for ICAS/EAS in patients with cerebral infarction(all P<0.05).Conclusion Serum UA level can better reflect the severity of ICAS/EAS in patients with cerebral infarction,and it is an independent risk factor of ICAS/EAS.
作者
苑宝文
李筹忠
陈瑜峰
魏玲
YUAN Baowen;LI Chouzhong;CHEN Yufeng;WEI Ling(Department of Internal Medicine-Neurology,Guizhou Orthopedic Hospital,Guizhou Province,Guiyang 550000,China;Department of Neurosurgery,Guizhou Provincial People’s Hospital,Guizhou Province,Guiyang 550000,China;Department of Acupuncture,the First People’s Hospital of Bijie City,Guizhou Province,Bijie 551700,China)
出处
《中国医药导报》
CAS
2021年第5期61-64,共4页
China Medical Herald
基金
贵州省卫生和计划生育委员会科学技术基金项目(gzwjkj2018-2-56)。
关键词
脑梗死
颅内外动脉粥样硬化性狭窄
尿酸
危险因素
Cerebral infarction
Intracranial/external atherosclerotic stenosis
Uric acid
Risk factor
