摘要
目的:探讨化脓性牙髓炎患者血清C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)及白细胞分化抗原-14(CD14)水平的变化及其临床意义。方法:选取2016年1月~2017年12月期间本院收治的110例化脓性牙髓炎患者为研究组,其中急性化脓性牙髓炎患者59例(急性组),慢性化脓性牙髓炎患者51例(慢性组),另选同期在我院进行健康检查的健康受试者50例为对照组。放射免疫分析法检测对照组体检时、研究组患者治疗前后血清CRP、IL-6、TNF-α及CD14水平。Pearson相关性分析化脓性牙髓炎患者治疗前血清CRP、IL-6、TNF-α与CD14水平的相关性。结果:研究组患者治疗前血清CRP、IL-6、TNF-α、CD14水平均高于对照组体检时各项指标水平,组间对比差异有统计学意义(P<0.05)。急性组患者治疗前后血清CRP、IL-6、TNF-α、CD14水平均高于慢性组患者(P<0.05);急性组、慢性组患者治疗后血清CRP、IL-6、TNF-α、CD14水平均低于治疗前(P<0.05)。Pearson相关性分析结果显示,化脓性牙髓炎患者治疗前血清CRP、IL-6、TNF-α与CD14水平均呈正相关(P<0.05)。结论:化脓性牙髓炎患者血清CRP、IL-6、TNF-α及CD14均呈现高表达,可能参与了化脓性牙髓炎的发生、发展过程,经牙髓根管治疗后上述指标水平均降低,且CD14与血清CRP、IL-6、TNF-α呈正相关,可能作为评估化脓性牙髓炎病情的重要指标。
Objective: To investigate the changes of serum C-reactive protein(CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and leukocyte differentiation antigen-14(CD14) in patients with suppurative pulpitis and their clinical significance. Methods:110 patients with suppurative pulpitis in our hospital from January 2016 to December 2017 were selected as the study group. Among them, 59 patients with acute suppurative pulpitis(acute group) and 51 patients with chronic suppurative pulpitis(chronic group), another50 healthy subjects were selected as the control group. The levels of serum CRP, IL-6, TNF-α and CD14 in the control group and the study group before and after treatment were measured by radioimmunoassay. Pearson correlation was used to analyze the correlation of serum CRP, IL-6, TNF-α and CD14 levels in patients with suppurative pulpitis before treatment. Results: The levels of serum CRP, IL-6,TNF-α and CD14 in the study group were higher than those in the control group before treatment, and there was significant difference between the two groups(P < 0.05). The levels of serum CRP, IL-6, TNF-α and CD14 in the acute group were higher than those in the chronic group before and after treatment(P < 0.05). The levels of serum CRP, IL-6, TNF-α and CD14 in the acute group and the chronic group were lower than those before treatment(P< 0.05). The results of Pearson correlation analysis showed that serum CRP, IL-6, TNF-αand CD14 levels were positively correlated before treatment in patients with suppurative pulpitis(P < 0.05). Conclusion: Serum CRP,IL-6, TNF-α and CD14 are all highly expressed in patients with suppurative pulpitis, which may be involved in the occurrence and development of suppurative pulpitis. After endodontic treatment, the above indexes are all decreased, and CD14 is positively correlated with serum CRP, IL-6 and TNF-α, which can be used as an important index to evaluate the condition of suppurative pulpitis.
作者
王晓敏
曹伟靖
杜莉
田莹
张乐
WANG Xiao-min;CAO Wei-jing;DU Li;TIAN Ying;ZHANG Le(Department of Oral Medicine,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,716000,China)
出处
《现代生物医学进展》
CAS
2020年第23期4593-4596,共4页
Progress in Modern Biomedicine
基金
陕西省卫生计生委科研基金项目(2016D1281)。
