摘要
肿瘤相关脑梗死的发病机制复杂,且肿瘤相关机制和多种传统机制共同参与脑梗死的发生。在肿瘤相关性卒中病因中,肿瘤的直接作用、凝血功能异常、非细菌性血栓性心内膜炎、感染和内皮损伤等机制都与肿瘤直接相关;而化疗、放疗、内分泌治疗和侵入性治疗等针对肿瘤的治疗也可通过相关的病理生理学机制引起脑梗死的发生。不同病理生理学机制相互交叉,共同导致了脑梗死的发生。
The pathogenesis of cancer-associated ischemic stroke is complicated,and cancerassociated mechanisms and a variety of traditional mechanisms are jointly involved in the occurrence of ischemic stroke.The mechanisms directly related to cancer include the direct effect of cancer,abnormal blood coagulation,nonbacterial thrombotic endocarditis,infection and endothelial cell injury;in addition,the cancer treatment,including chemotherapy,radiotherapy,endocrine therapy and invasive treatment,can also cause stroke through related pathophysiological mechanism.Some pathophysiological mechanisms interact each other and jointly contribute to the occurrence of ischemic stroke.
作者
杨启舟
付睿
王莉莉
YANG Qi-Zhou;FU Rui;WANG Li-li(Department of Neurology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)
出处
《中国卒中杂志》
2021年第2期123-129,共7页
Chinese Journal of Stroke
关键词
肿瘤
脑梗死
发病机制
Cancer
Ischemic stroke
Pathogenesis
