摘要
核受体结合SET结构域蛋白2(nuclear receptor binding SET domain-protein 2,NSD2)是组蛋白甲基转移酶(HMTases)家族中的一员,利用其含有的SET结构域主要催化组蛋白H3赖氨酸第36号位(H3K36)的二甲基化(H3K36me2),进一步发挥基因调控作用。组蛋白的甲基化修饰作为表观遗传学中重要的调控机制,在转录调控以及染色质重构等多种生物学过程中发挥重要作用。一些报道将NSD2描述为致癌基因,其在多种肿瘤中高表达,并与肿瘤的恶性程度及预后相关。NSD2在前列腺癌中的高表达,不仅参与前列腺癌的发生发展,更促进其侵袭转移,深入探究NSD2的作用机制将促进相关靶向药物的发展,为前列腺癌提供新的治疗方案。
Nuclear receptor binding SET domain-protein 2(NSD2)is a member of the HMTases family,and its SET domain mainly catalyzes the dimethylation of histone H3 lysine at position 36(H3K36)to further play the role of gene regulation.As an important regulatory mechanism in epigenetics,histone methylation plays an important role in transcriptional regulation,chromatin remodeling and other biological processes.Some reports have described NSD2 as an oncogene,which is highly expressed in a variety of tumors and is associated with tumor malignancy and prognosis.The high expression of NSD2 in prostate cancer not only promotes the occurrence and development of prostate cancer,but also promotes its invasion and metastasis.Further exploration of the mechanism of NSD2 will promote the development of relevant targeted drugs and provide new treatment schemes for prostate cancer.
作者
张佳佳
石光跃
ZHANG Jiajia;SHI Guangyue(Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第6期1076-1079,共4页
Journal of Modern Oncology
关键词
NSD2
前列腺癌
转移
治疗
NSD2
prostate cancer
metastasis
treatment
