摘要
目的分析血清分泌型卷曲相关蛋白-4(SFRP-4)水平与2型糖尿病肾病患者胰岛素抵抗、肾功能及肾纤维化指标的关系。方法选择2017年1月—2019年12月广东省江门市中心医院/中山大学附属江门医院肾内科收治2型糖尿病肾病患者84例作为糖尿病肾病组(DN组),单纯2型糖尿病患者86例作为单纯糖尿病组(DM组),同期体检的健康者80例作为健康对照组。比较各组血清SFRP-4、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)指标、肾功能指标、肾纤维化指标,并分析SFRP-4水平与上述指标的相关性。结果DN组SFRP-4、FINS、HOMA-IR、SCr、BUN、UA、尿β2-MG、TGF-β1、TIMP-1、CⅣ、CTGF水平高于DM组和健康对照组(F/P=92.392/0.000、11.297/0.008、12.346/0.000、29.354/0.000、8.965/0.007、42.286/0.000、8.762/0.021、42.348/0.000、78.392/0.000、32.293/0.000、7.281/0.043),Alb水平低于DM组和健康对照组(F/P=28.254/0.000),DM组SFRP-4、FPG、FINS、HbA1c、HOMA-IR、SCr、BUN、UA、尿β2-MG水平高于健康对照组,Alb水平低于健康对照组(P均<0.05)。DM组与健康对照组TGF-β1、TIMP-1、CⅣ、CTGF水平比较差异无统计学意义(P>0.05)。Pearson相关分析显示,糖尿病肾病患者血清SFRP-4水平与FPG、FINS、HbA1c、HOMA-IR、SCr、BUN、UA、尿β2-MG、TGF-β1、TIMP-1、CⅣ、CTGF呈正相关(r/P=0.367/0.022、0.387/0.012、0.322/0.032、0.473/0.004、0.437/0.013、0.524/0.000、0.405/0.008、0.412/0.018、0.378/0.019、0.383/0.009、0.402/0.012、0.398/0.016),与Alb呈负相关(r/P=-0.377/0.009)。结论2型糖尿病肾病患者血清SFRP-4水平升高,其与胰岛素抵抗、肾功能及肾纤维化均有一定相关性,可能参与了糖尿病肾病的发生发展,具有辅助评估糖尿病肾病病情的潜力。
Objective To analyze the relationship between serum secreted frizzled-related protein-4(SFRP-4)levels and insulin resistance,renal function and renal fibrosis indicators in patients with type 2 diabetic nephropathy.Methods From January 2017 to December 2019,84 patients with type 2 diabetic nephropathy admitted to the Department of Nephrology,Jiangmen Central Hospital/Jiangmen Hospital Affiliated to Sun Yat-sen University in Guangdong Province were selected as the diabetic nephropathy group(DN group),and 86 patients with simple type 2 diabetes were selected as simple In the diabetes group(DM group),80 healthy people who received physical examination during the same period served as the healthy control group.Compare serum SFRP-4,fasting blood glucose(FPG),fasting insulin(FINS),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR)indicators,renal function indicators,renal fibrosis indicators,and analyze the relationship between SFRP-4 levels and the above indicators Correlation.Results The levels of SFRP-4,FINS,HOMA-IR,SCr,BUN,UA,urineβ2-MG,TGF-β1,TIMP-1,CⅣ,and CTGF in the DN group were higher than those in the DM group and the healthy control group(F/P=92.392/0.000,11.297/0.008,12.346/0.000,29.354/0.000,8.965/0.007,42.286/0.000,8.762/0.021,42.348/0.000,78.392/0.000,32.293/0.000,7.281/0.043),the Alb level was lower than the DM group and the healthy control group(F/P=28.254/0.000),the levels of SFRP-4,FPG,FINS,HbA1c,HOMA-IR,SCr,BUN,UA,and urineβ2-MG in the DM group were higher than those in the healthy control group,and the Alb levels were lower than those in the healthy control group(all P<0.05).There was no significant difference in the levels of TGF-β1,TIMP-1,CⅣand CTGF between the DM group and the healthy control group(P>0.05).Pearson correlation analysis showed that serum SFRP-4 levels in diabetic nephropathy patients were positively correlated with FPG,FINS,HbA1c,HOMA-IR,SCr,BUN,UA,urineβ2-MG,TGF-β1,TIMP-1,CⅣ,and CTGF(r/P=0.367/0.022,0.387/0.012,0.322/0.032,0.473/0.004,0.437/0.013,0.524/0
作者
徐庆东
郭焕开
陈洁欣
邓继鸿
苏明
马惠娟
姜松青
石晓峰
Xu Qingdong;Guo Huankai;Chen Jiexin;Deng Jihong;Su Ming;Ma Huijuan;Jiang Songqing;Shi Xiaofeng(Department of Nephrology, Jiangmen Central Hospital/Jiangmen Hospital Affiliated to Zhongshan University, Guangdong Province,Jiangmen 529030,China)
出处
《疑难病杂志》
CAS
2021年第2期158-162,共5页
Chinese Journal of Difficult and Complicated Cases
基金
广东省医学科研基金立项项目(A20193192)。
关键词
糖尿病
2型
糖尿病肾病
分泌型卷曲相关蛋白-4
胰岛素抵抗
肾功能
肾纤维化
Diabetic,type 2
Diabetic nephropathy
Secretory curl associated protein-4
Insulin resistance
Renal function
Renal fibrosis
