摘要
雪松醇(Cedrol,CE),是一种用途极为广泛的天然倍半萜醇,广泛存在于柏科、杉科及松科等多种植物的挥发油中。研究报道CE存在多种药理作用,包括抗炎镇痛、对心脑血管系统作用、抗肿瘤、促进头发生长、抗菌、抗疟原虫活性等。为拓宽其应用,加速其新药研发进程,有必要对其研究进行总结。通过查阅相关文献,归纳总结了CE的提取与检测以及其在合成中的应用,探讨了近年来CE的药理作用及其可能的作用机制,并分析了未来发展方向,为其应用以及新药研发提供参考。
Cedrol(CE),a natural sesquiterpene alcohol with a very wide range of uses,is widely present in the volatile oils of various plants such as Cupressaceae,Taxaneae and Pinaceae.CE has a variety of pharmacological effects,including anti-inflammatory and analgesic effects,effects on the cardiovascular and cerebrovascular systems,anti-tumor,hair growth promotion,antibacterial,and anti-plasmodium activities.In order to broaden its application and accelerate its new drug development process,it is necessary to summarize it.This work summarizes the extraction and detection of CE and its application in synthesis by consulting related literature,discusses the pharmacological effects and possible mechanisms of CE in recent years,and analyzes its future development direction,its application and new drugs R&D provides reference.
作者
汤陆扬
卢小鸾
杨敏
付阳洋
孙晓霞
彭黔荣
杨培昕
TANG Lu-yang;LU Xiao-luan;YANG Min;FU Yang-yang;SUN Xiao-xia;PENG Qian-rong;YANG Pei-xin(School of Pharmacy,Guizhou University,Guiyang 550025,China;Technical Center of China Tobacco Guizhou Industry Co.,Ltd.,Guiyang 550000,China)
出处
《化学试剂》
CAS
北大核心
2021年第1期48-54,共7页
Chemical Reagents
基金
国家自然科学基金项目(21562014)
贵州中烟科技项目(黔烟工技[2015]8号)。
关键词
雪松醇
提取与检测
合成
药理作用
cedrol
extraction and detection
synthesis
pharmacological effects
