摘要
目的研究艾地苯醌联合多巴丝肼治疗帕金森病的临床疗效及其对α-突触核蛋白(α-Syn)、生长分化因子-15(GDF-15)水平的影响。方法选取2013年8月—2018年2月湖北省天门市第一人民医院住院的120例帕金森病患者作为研究对象,按照随机数字表将患者随机分为对照组和观察组,每组患者60例。对照组患者口服多巴丝肼片,根据患者的临床症状及疾病严重程度,首次剂量为1/2片,3次/d,每周增加1/2片,根据患者的疾病严重程度,维持剂量为2~4片/d。观察组患者在此基础上联合使用艾地苯醌片,30 mg/次,3次/d。两组患者均治疗3个月。观察两组患者的临床疗效,同时比较两组治疗前后的运动功能和血清学指标。结果观察组患者的治疗有效率为75.00%,显著高于对照组的55.00%,差异存在统计学意义(P<0.05)。治疗后,两组患者的帕金森病统一评分量表第三部分(UPDRSⅢ)、帕金森病运动功能评定量表(MDRSPD)显著降低,左手计时运动次数、右手计时运动次数显著升高(P<0.05),且观察组患者的UPDRSⅢ、MDRSPD显著低于对照组,左手计时运动次数、右手计时运动次数显著高于对照组(P<0.05)。治疗后,两组患者的α-Syn、GDF-15水平均显著降低(P<0.05),且观察组患者的α-Syn、GDF-15水平显著低于对照组(P<0.05)。结论艾地苯醌联合多巴丝肼治疗帕金森患者效果显著,可显著降低α-Syn和GDF-15水平,建议临床推广。
Objective To investigate the clinical efficacy of idebenone combined levodopa and benserazide hydrochloride in treatment of Parkinson’s disease,and its effect onα-Syn and GDF-15 levels.Methods A total of 120 patients with Parkinson’s disease admitted to The First People’s Hospital of Tianmen in Hubei Province from August 2013 to February 2018 were selected as the study subjects.According to the random number table,the patients were randomly divided into the control group and observation group,with 60 patients in each group.Patients in the control group were po administered with Levodopa and Benserazide Hydrochloride Tablets,the first dose was 1/2 tablet,3 times daily,and 1/2 tablet was added weekly according to the clinical symptoms and disease severity of the patients.The maintenance dose was 2—4 tablets daily.Patients in the observation group were po administered with Idebenone Tablets on the basis of control group,30 mg/time,and 3 times daily.Patients in both groups were treated for 3 months.The clinical efficacy of the two groups was observed,and the motor function and serological indexes were compared before and after treatment.Results The effective rate of patients in the observation group was 75.00%,which was significantly higher than 55.00%in the control group,with statistically significant difference(P<0.05).After treatment,UPDRSⅢ,MDRSPD scores in two groups were decreased significantly,and the left hand timing movement frequency,right timing movement times were significantly increased(P<0.05),and UPDRSⅢand MDRSPD scores were significantly lower than those in the control group,the left hand timing movement number of times,right timing movement were significantly higher than those in the control group(P<0.05).After treatment,the levels ofα-Syn and GDF-15 in two groups were significantly decreased(P<0.05),and the levels ofα-Syn and GDF-15 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The combination of idebenone combined levodopa and ben
作者
黄骥
阳军
欧阳娟
徐蜜
HUANG Ji;YANG Jun;OUYANG Juan;XU Mi(Department of Neurology,The First People's Hospital of Tianmen in Hubei Province,Tianmen 431700,China;Department of Medical Technology Teaching and Research,Tianmen Vocational College,Tianmen 431700,China;Department of Laboratory,The First People's Hospital of Tianmen in Hubei Province,Tianmen 431700,China;Department of Paediatrics,The First People's Hospital of Tianmen in Hubei Province,Tianmen 431700,China)
出处
《药物评价研究》
CAS
2020年第12期2501-2504,共4页
Drug Evaluation Research
