摘要
目的研究华山参(漏斗泡囊草Physochlaina infundibularis干燥根)的化学成分。方法采用正相硅胶、Sephadex LH-20、HPLC等色谱手段,对华山参药材进行分离纯化,并利用质谱、核磁共振等方法进行化合物结构鉴定。结果从华山参正丁醇部位初步分离得到3个酰胺类化合物,分别鉴定为N-甲酰基-N-阿魏酰基-1,4-丁二胺(1)、N-乙酰基-N-顺式阿魏酰基-1,4-丁二胺(2)、N-乙酰基-N-阿魏酰基-1,4-丁二胺(3)。结论化合物1、2为新化合物,分别命名为华山参丁二胺A、华山参丁二胺B;化合物3为首次从泡囊草属植物中分离得到。
Objective To study the chemical constituents of Physochlaina infundibularis.Methods The chemical constituents were isolated by chromatography with silica gel,HPLC,Sephadex LH-20.The structures were identified by MS and NMR analyses.Results Three amides were separated from P.infundibularis and elucidated as trans N-formyl-N-feruloyl-putrescine(1),cis N-acetyl-N-feruloyl-putrescine(2)and trans N-acetyl-N-feruloyl-putrescine(3).Conclusion Compounds 1 and 2 are new compounds,and compound 3 is separated from the genus Physochlaina for the first time.
作者
娄永
许睿珠
张丽萍
谢治深
张振强
徐江雁
李军
王潘
LOU Yong;XU Rui-zhu;ZHANG Li-ping;XIE Zhi-shen;ZHANG Zhen-qiang;XU Jiang-yan;LI Jun;WANG Pan(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第2期331-334,共4页
Chinese Traditional and Herbal Drugs
基金
国家重点研发计划-战略性国际科技创新合作专项(2020YFE0201800)
河南省科技攻关项目(202102310183,202102310173)
河南省中医药科学研究专项课题-重大项目(2018ZYZD12)。
