摘要
目的研究永康地区妊娠合并梅毒孕产妇的特征及所产婴儿感染梅毒的高危因素,以期为梅毒流行和母婴传播的防控提供参考。方法对2015-2018年永康地区的梅毒感染孕产妇及其所产婴儿的相关临床数据进行回顾性统计分析。结果2015-2018年,永康市共有孕产妇54573例,检测发现梅毒感染孕产妇220例,梅毒检测阳性率为0.40%。2015-2018年梅毒阳性率依次为0.41%、0.36%、0.35%及0.51%。梅毒感染孕产妇普遍文化程度低(初中及以下占69.55%),流动人口为主(68.64%),农村人口占比高(95.00%)。共分娩223例婴儿,活产220例,所产婴儿先天性梅毒发病2例(0.90%);除去失访的22例,其余198例均在12月龄之前转阴。母亲产前快速血浆反应素环状卡片试验(RPR)滴度、母亲梅毒诊疗时间点及胎儿性别可能为儿童梅毒血清学试验转阴时间的相关高风险因素。结论2015-2018年永康市妊娠梅毒的发病率无明显下降,新生儿先天梅毒的阳性率较低。母亲产前RPR滴度、母亲梅毒诊疗时间及胎儿性别与儿童梅毒血清学试验转阴延迟的相关性需引起高度关注。
Objective To analyze the characteristics of the pregnant women infected with syphilis,the outcomes and risk factors of infants born to maternal syphilis in Yongkang,to provide references for prevention of mother-to-child transmission of syphilis.Methods Retrospective analysis was conducted on the clinical data of the pregnant women infected with syphilis and infants,including syphilis test results,age,level of education,pregnancy outcome,treatment and follow-up results of the infants born in Yongkang during 2015-2018.Results The incidence of syphilis in pregnant women was 0.41%,0.36%,0.35%and 0.51%annually,with 220 cases found in 54573 pregnant women.Infection with syphilis was correlated with the lower educational level.Most of the pregnant women infected with syphilis were floating population or farmers.There were 223 infants.However,there were only two cases of congenital syphilis in the babies,and all the rest turned negative before the age of 12 months.The prenatal RPR titer,maternal syphilis diagnosis and treatment time and fetal sex were related risk factors for the negative conversion time of serological tests for syphilis in children.Conclusion There is no significant decrease in the incidence of gestational syphilis in Yonkang from 2015-2018.However,the positive rate of congenital syphilis in newborns is relatively low,indicating that the transmission of syphilis from mother to child has been effectively controlled.We should pay close attention to maternal RPR titer,diagnosis and treatment time,fetal sex,and the delay of negative conversion in syphilis serological test for children.
作者
姚爱媛
朱东波
吕颖
YAO Aiyuan;ZHU Dongbo;LYU Ying(Maternity and Childcare Hospital,Department of Children Healthcare,Yongkang 321300,Zhejiang,China;The first people's Hospital of Yongkang 321300,Zhejiang;The Children's Hospital Affiliated to Zhejiang University Medical College,Hangzhou 310000,Zhejiang)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2020年第12期1352-1354,1364,共4页
Chinese Journal of Aids & STD
关键词
妊娠合并梅毒
先天性梅毒
母婴传播
高风险因素
syphilis during pregnancy
congenital syphilis
mother to child transmission
high risk factors
